DNA Damage/DNA Repair
- MTH1(4)
- PARP(78)
- ATM/ATR(29)
- DNA Alkylating(25)
- DNA Ligases(3)
- DNA Methyltransferase(21)
- DNA-PK(31)
- HDAC(124)
- Nucleoside Antimetabolite/Analogue(160)
- Telomerase(16)
- Topoisomerase(175)
- tankyrase(5)
- Antifolate(33)
- CDK(271)
- Checkpoint Kinase (Chk)(33)
- CRISPR/Cas9(9)
- Deubiquitinase(76)
- DNA Alkylator/Crosslinker(72)
- DNA/RNA Synthesis(472)
- Eukaryotic Initiation Factor (eIF)(27)
- IRE1(23)
- LIM Kinase (LIMK)(12)
- TOPK(6)
- Casein Kinase(61)
- DNA Intercalating Agents(8)
- DNA/RNA Oxidative Damage(13)
- Poly(ADP-ribose) Glycohydrolase (PARG)(1)
- Early 2 Factor (E2F)(1)
Products for DNA Damage/DNA Repair
- Cat.No. Product Name Information
-
GC60023
3'-Deoxyuridine-5'-triphosphate
3'-dUTP
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. -
GC61862
3'-Deoxyuridine-5'-triphosphate trisodium
3'-dUTP trisodium
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. -
GC45332
3'-Dephosphocoenzyme A
depCoA, Dephospho-CoA
An intermediate in the biosynthesis of CoA -
GC34384
3,6-DMAD hydrochloride
3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research of cancer.
-
GC34452
3,7,4'-Trihydroxyflavone
3,7,4'-Trihydroxyflavone, isolated from Rhus javanica var.
-
GC52129
3-Amino-5-hydroxybenzoic Acid
AHBA
-
GC13510
3-AP
3-Aminopyridine-2-Carboxyaldehyde Thiosemicarbazone,NSC 663249,Triapine™
ribonucleotide reductase inhibitor and iron chelator with antitumor activity -
GC48457
3-keto Fusidic Acid
3-keto FA, 3-Oxofusidic Acid
An active metabolite of fusidic acid -
GC65084
3-Methylcytidine
3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
-
GC52391
306-O12B-3
An ionizable cationic lipidoid
-
GC15389
360A
-
GC10115
360A iodide
-
GC14493
4μ8C
4u8C
IRE1 Rnase inhibitor, potent and non-toxic
-
GC17271
4'-Demethylepipodophyllotoxin
(-)-4′-Demethylepipodophyllotoxin
An inhibitor of tubulin polymerization -
GC46607
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
NNK
A tobacco-specific nitrosamine carcinogen -
GC11761
4-amino-1,8-Naphthalimide
4-Aminonaphthalimide,4-ANI
4-amino-1,8-Naphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells. -
GC42401
4-hydroperoxy Cyclophosphamide
4-OOH-CY
4-hydroperoxy Cyclophosphamide, the active metabolite of cyclophosphamide, can cross-link DNA and induce T cell apoptosis independently of caspase receptor activation. It also activates the mitochondrial death pathway through the production of reactive oxygen species (ROS). -
GC68332
4-Hydroperoxy Cyclophosphamide-d4
-
GC18853
4-isocyanato TEMPO
4-isocyanato TEMPO is a spin labeling reagent used to label the 2'-position in RNA.
-
GC61683
4-Methoxyphenethyl alcohol
4-Methoxyphenethyl alcohol, an aromatic alcohol, is the major component in the anise-like odour produced by A.
-
GC49127
4-oxo Cyclophosphamide
4-keto CP, 4-keto Cyclophosphamide, NSC 139488, 4-oxo CP
An inactive metabolite of cyclophosphamide -
GC42464
4-oxo-2-Nonenal
4-ONE
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.
-
GC45353
4-oxo-27-TBDMS Withaferin A
4-oxo-27-TBDMS Withaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.4-oxo-27-TBDMS Withaferin A induces tumor cells apoptosis. 4-oxo-27-TBDMS Withaferin A is a anticancer agent.
-
GC68557
4-Thio-2'-deoxyuridine
2′-Deoxy-4-thiouridine; 4-Thiodeoxyuridine
4-Thio-2'-deoxyuridine is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity, targeting inert lymphatic system malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis and inducing cell apoptosis.
-
GC40477
4-Thiouracil
2-hydroxy-4-Mercaptopyrimidine, NSC 43288, 4-Thiopyrimidin-2-one, 4-TU
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. -
GC42474
4-Thiouridine
NSC 518132, 4-SU
4-Thiouridine(4sU) is a ribonucleoside analogue that can be used for RNA analysis and (m)RNA labeling. -
GC13104
4E1RCat
eIF4E/eIF4G Interaction Inhibitor II
Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction -
GC30785
4E2RCat
4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
-
GC10468
4EGI-1
eIF4E/eIF4G Interaction Inhibitor
Competitive eIF4E/eIF4G interaction inhibitor -
GC12667
4SC-202
4SC-202 (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).
-
GC73521
5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite
N1-Methylpseudouridine CEP
5'-DMT-2'-O-TBDMS-N1-Metl-PseudoUridine-CE-Phosphoramidite is a purine nucleoside analog. -
GC65520
5'-DMT-3'-TBDMS-ibu-rG
5'-DMT-3'-TBDMS-ibu-rG is is a modified nucleoside.
-
GC65402
5'-O-DMT-2'-O-TBDMS-Bz-rC
5'-O-DMT-2'-O-TBDMS-Bz-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
-
GC65164
5'-O-DMT-2'-O-TBDMS-rI
5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside.
-
GC65396
5'-O-DMT-ibu-dC
5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.
-
GC64982
5'-O-DMT-N2-DMF-dG
5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside.
-
GC65482
5'-O-DMT-N6-ibu-dA
5'-O-DMT-N6-ibu-dA can be used in the synthesis of oligodeoxyribonucleotides.
-
GC65562
5'-O-DMT-N6-Me-2'-dA
5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects.
-
GC65401
5'-O-TBDMS-dU
5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides.
-
GC71033
5'-ODMT cEt G Phosphoramidite (Amidite)
5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog.
-
GC71035
5'-ODMT cEt m5U Phosphoramidite (Amidite)
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog.
-
GC73179
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
5'-ODMT cEt N-Bz A Phosphoramidite Amidite is a locked nucleic acid (LNA) analogue.
-
GC71034
5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog.
-
GC62157
5’-O-DMT-2’-O-TBDMS-Ac-rC
5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
-
GC62149
5’-O-DMT-2’-TBDMS-Uridine
5’-O-DMT-2’-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.
-
GC62532
5’-O-DMT-3’-O-TBDMS-Ac-rC
5’-O-DMT-3’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
-
GC62573
5’-O-DMT-Bz-rC
5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.
-
GC62574
5’-O-DMT-N4-Ac-2’-F-dC
5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.
-
GC62575
5’-O-DMT-N4-Bz-2’-F-dC
5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.
-
GC62576
5’-O-DMT-N4-Bz-5-Me-dC
5’-O-DMT-N4-Bz-5-Me-dC is a modified nucleoside.
-
GC62812
5’-O-DMT-PAC-dA
5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides.
-
GC62813
5’-O-DMT-rI
5'-O-DMT-Ri can be used in the synthesis of oligoribonucleotides.
-
GC62578
5’-O-TBDMS-Bz-dA
5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.
-
GC62579
5’-O-TBDMS-dA
5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
-
GC62580
5’-O-TBDMS-dG
5’-O-TBDMS-dG is a modified nucleoside.
-
GC62581
5’-O-TBDMS-dT
5’-O-TBDMS-dT is a nucleoside with protective and modification effects.
-
GC40641
5'-Ethynyl-2'-deoxycytidine
EdC, 2'-deoxy-5-Ethynylcytidine
5'-Ethynyl-2'-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 μg/mL). -
GC61432
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine?is an adenosine derivative and can be used as an intermediate for oligonucleotides synthesis.
-
GC61726
5'-O-DMT-N4-Ac-dC
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis.
-
GC48662
5'-Thymidylic Acid (sodium salt)
Deoxythymidine-5’-monophosphate, Thymidine monophosphate, Thymidine-5’-monophosphate, dTMP
5'-Thymidylic Acid (sodium salt) is an endogenous metabolite. -
GC35150
5,7,4'-Trimethoxyflavone
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner.
-
GC90796
5-(3-Aminoallyl)-2'-deoxyuridine-5'-O-triphosphate (sodium salt)
An amine-modified nucleotide
-
GC90823
5-(3-Aminoallyl)uridine-5'-O-triphosphate (sodium salt)
An amine-modified nucleotide
-
GC68161
5-AIQ
5-Aminoisoquinolin-1-one
-
GC90549
5-Aminoimidazole-4-carboxamide (hydrate)
A synthetic precursor
-
GC73073
5-Aza-4'-thio-2'-deoxycytidine
5-Aza-T-dCyd; NTX-301
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA metltransferase I (DNMT1) inhibitor. -
GC64952
5-Aza-7-deazaguanine
5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides.
-
GC10946
5-Azacytidine
Antibiotic U 18496, 5AzaC, Ladakamycin, Mylosar, NSC 102816, NSC 103627, U 18496, WR 183027
5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively. -
GC73520
5-Azidomethyl-2'-deoxyuridine
5-AmdU; α-Azidothymidine
5-Azidometl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog. -
GC11940
5-BrdU
BrdU, Bromodeoxyuridine, Broxuridine, NSC 38297
5-BrdU (5-bromo-2-deoxundine5-BrdU) is a synthetic thymidine bromide analog that is commonly used to measure DNA synthesis and label dividing cells. -
GC46681
5-Bromouridine
(-)-5-Bromouridine, BrU, BrUrd, NSC 38296
A brominated uridine analog -
GC71207
5-Ethyluridine
5-Ethyluridine is a purine nucleoside analogue.
-
GC49245
5-Ethynyluridine
5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA.
-
GC71361
5-Fluoro-2′-deoxy-UTP
5-Fluoro-2′-deoxy-UTP can be used as a substrate for DNA synthesis.
-
GC42545
5-Fluorouracil-13C,15N2
5-FU-13C,15N2
5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. -
GC46033
5-Heneicosylresorcinol
An alkylresorcinol
-
GC62389
5-Iminodaunorubicin
5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells.
-
GC35162
5-Iodo-indirubin-3'-monoxime
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively.
-
GC66658
5-Me-dC(Ac) amidite
5-Me-dC(Ac) amidite is used for synthesizing DNA or RNA.
-
GC31187
5-Methoxyflavone
5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
-
GC42562
5-Methyl-2'-deoxycytidine
5Methyldeoxycytidine
5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. -
GC67671
5-Methylcytidine 5′-triphosphate trisodium
5-Methyl-CTP trisodium
-
GC35166
5-Methylcytosine
5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes.
-
GC62547
5-O-TBDMS-N4-Benzoyl-2-deoxycytidine
5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside.
-
GC70654
5-PA-dUTP
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery.
-
GC66055
5-Phenylpentan-2-one
5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research.
-
GC46713
5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate)
Phosphoribosyl Pyrophosphate, P-rib-PP, PRPP
An intermediate in several biochemical pathways -
GC73009
5-Propargylamino-3'-azidomethyl-dCTP TEA
5-Propargylamino-3'-azidometl-dCTP (TEA) is a nucleotide molecule that can be used in DNA synthesis and DNA sequencing.
-
GC73008
5-Propargylamino-3'-azidomethyl-dUTP tristriethylamine
5-Propargylamino-3'-azidometl-dUTP tristrietlamine is a nucleotide molecule that can be used in DNA synthesis and DNA sequencing.
-
GC70655
5-Propargylamino-ddCTP trisodium
5-Propargylamino-ddCTP (trisodium), a nucleoside molecule that can be used to synthesis of cyanine dye-nucleotide conjugate which is used in nucleic acid labeling or sequence analysis.
-
GC46079
5-Tricosylresorcinol
5-Tricosylresorcinolthe is the first cyst lipid.
-
GC45772
6(5H)-Phenanthridinone
NSC 11021, NSC 40943, NSC 61083
An inhibitor of PARP1 and 2 -
GC60532
6-(Dimethylamino)purine
6-(Dimethylamino)purine is a dual inhibitor of protein kinase and CDK.
-
GC30548
6-Amino-5-nitropyridin-2-one
6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine.
-
GC60031
6-Azathymine
6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor.
-
GC50249
6-Hydroxy-DL-DOPA
6-Hydroxy-DL-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DL-DOPA can be used for the research of cancer.
-
GC32975
6-Mercaptopurine hydrate
6-MP
An inhibitor of purine synthesis and interconversion -
GC35180
6-Methyl-5-azacytidine
6-Methyl-5-azacytidine is a potent DNMT inhibitor.
-
GC49235
6-Methylmercaptopurine
6-MMP, 6-(Methylthio)purine, NSC 20105, SQ 8,343
A metabolite of 6-mercaptopurine -
GC49488
6-Methylmercaptopurine-d3
6-MMP-d3, 6-(Methylthio)purine-d3
An internal standard for the quantification of 6-MMP