(±)5-HETE lactone (Synonyms: (±)5-Hydroxyeicosatetraenoic Acid lactone) |
カタログ番号GC40828 |
(±)5-HETEラクトンは、(±)5-HETEのC-5ヒドロキシル基がC-1カルボキシル基に酸触媒下で求核付加反応を起こして形成される環状エステルです。
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Cas No.: 73279-37-5
Sample solution is provided at 25 µL, 10mM.
(±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. (±)5-HETE lactone is an inhibitor of 5-lipoxygenase from rat basophilic leukemia cells with an IC50 of 27 µM. The lactone is several times more potent than the linear (±)5-HETE.
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