Bifenthrin (Synonyms: (±)-Bifenthrin) |
カタログ番号GC60642
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Bifenthrinはピレスロイドの殺虫剤であり、その精神毒性の作用の主な標的は、ニューロン細胞膜の電位依存性のNa+チャネルである。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 82657-04-3
Sample solution is provided at 25 µL, 10mM.
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Bifenthrinはピレスロイドの殺虫剤であり、その精神毒性の作用の主な標的は、ニューロン細胞膜の電位依存性のNa+チャネルである[1]。Bifenthrinはより大きい光安定性と殺虫活性を持つものの、様々な動物に対して神経毒性を持ち、その毒性の臨床症状には、震えと痙攣が含まれている[1, 2]。
Bifenthrin（20μM；24時間）は初代小膠細胞で、 PGE2、NOとTNF-alphaの産生を著しく増やした；Bifenthrin（20μM；24時間）は初代小膠細胞でIL-6とTNF-alpha mRNAの発見を増やした[3]。Bifenthrin（1、1.5μM；24時間）は赤血球でグルタミン酸ペルオキシダーゼの活性を著しく減らした；Bifenthrin（1.5μM；24時間）は赤血球で溶血を誘発した[2]。
Bifenthrin（30、60ng/L；14日間）は幼魚のニジマスの充血した血管の数を増やした[4]。Bifenthrin（8mg/kg；7日間；腹腔内注射）は一部のBALB/cマウスの標本の肝臓組織で、局在的な核濃縮と液胞変性を誘発した；Bifenthrin（2、4、8mg/kg；7日間；腹腔内注射）はBALB/cマウスのミトコンドリアROS生成で、濃度依存的な増加を起こした[5]。Bifenthrin（0.6mg/kg；6週間；隔日；胃内投与）はC57BL/6マウスの体重を著しく増やした；Bifenthrin（0.6mg/kg； 6週間；隔日；胃内投与）はC57BL/6マウスで、HSLとATGLの発見を著しく下方制御し、同時にLPLの発見を著しく上方制御した[6]。
References:
[1] Moreira C V L, Ogbu J s, Monteiro K L C, et al. Bifenthrin under scrutiny: revisiting toxicological evidence amid regulatory gaps [J]. Journal of applied toxicology : JAT, 2026, 46(1): 61-77.
[2] Mukhtar F, Jilani K, Bibi I, et al. Stimulation of erythrocyte membrane blebbing by Bifenthrin induced oxidative stress [J]. Dose-response : a publication of International Hormesis Society, 2022, 20(1): 15593258221076710.
[3] Gargouri B, Yousif N M, Bouchard M, et al. Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures [J]. Journal of neuroinflammation, 2018, 15(1): 159.
[4] Magnuson J T, Caceres L, Sy N, et al. The use of non-targeted lipidomics and histopathology to characterize the neurotoxicity of Bifenthrin to juvenile rainbow trout (Oncorhynchus mykiss) [J]. Environmental science & technology, 2022, 56(16): 11482-11492.
[5] Zhang Y, Lu M, Zhou P, et al. Multilevel evaluations of potential liver injury of bifenthrin [J]. Pesticide biochemistry and physiology, 2015, 122: 29-37.
[6] Wei C, Wang X, Yao X, et al. Bifenthrin induces fat deposition by improving fatty acid uptake and inhibiting lipolysis in mice [J]. Journal of agricultural and food chemistry, 2019, 67(51): 14048-14055.
| 細胞実験[1]: | |
細胞株 | Sprague Dawleyラットの初代小膠細胞 |
準備方法 | 小膠細胞をBifenthrin（対照物としてのDMSO）に24時間暴露した。TNF-alphaとIL-6の遺伝子発見を、リアルタイム定量化PCRで分析した。 |
反応条件 | 20μM；24時間 |
アプリケーション | Bifenthrinは、初代小膠細胞で、IL-6とTNF-alpha mRNAの発見を増やした。 |
| 動物実験 [2]: | |
動物モデル | BALB/cマウス |
準備方法 | コーン油の中、適切な濃度で、0.3 mLのBifenthrinを動物に腹腔内注射した。7日間の処理期の後、分析の為に、肝臓を採取した。 |
投与形態 | 2、4、8mg/kg；7日間；腹腔内注射 |
アプリケーション | Bifenthrinは、ミトコンドリアROSの生成を濃度依存的に増やした。 |
References: | |
| Cas No. | 82657-04-3 | SDF | |
| 同義語 | (±)-Bifenthrin | ||
| Canonical SMILES | O=C([C@H]1C(C)(C)[C@H]1/C=C(Cl)/C(F)(F)F)OCC2=C(C)C(C3=CC=CC=C3)=CC=C2 | ||
| Formula | C23H22ClF3O2 | M.Wt | 422.87 |
| 溶解度 | DMSO: 100 mg/mL (236.48 mM) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3648 mL | 11.824 mL | 23.6479 mL |
| 5 mM | 473 μL | 2.3648 mL | 4.7296 mL |
| 10 mM | 236.5 μL | 1.1824 mL | 2.3648 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)