Bifenthrin (Synonyms: (±)-Bifenthrin) |
Catalog No.GC60642
One-Click Copy Product Info
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Bifenthrin은 피레스로이드 계열 살충제로 신경 독성 작용의 주요 표적은 신경세포 막의 전압 개입 Na+ 채널이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 82657-04-3
Sample solution is provided at 25 µL, 10mM.
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Bifenthrin은 피레스로이드 계열 살충제로 신경 독성 작용의 주요 표적은 신경세포 막의 전압 개입 Na+ 채널이다. Bifenthrin은 광안정성과 살충 활성이 우수하지만 다양한 동물에게 신경독성을 나타내고 독성의 임상 징후로는 떨림과 경련을 포함한다[1, 2].
Bifenthrin(20μM; 24시간)은 1차 미세아교세포에서 PGE2, NO 및 TNF-알파 생성을 현저하게 증가시켰다; Bifenthrin(20μM; 24h)은 1차 미세아교세포에서 IL-6 및 TNF-알파 mRNA 발현을 증가시켰다[3]. Bifenthrin(1, 1.5μM; 24h)은 적혈구에서 글루타티온 퍼옥시다제 활성을 현저하게 감소시켰다; Bifenthrin(1.5μM; 24h)은 적혈구에서 용혈을 유도하였다[2].
Bifenthrin(30, 60ng/L; 14일)은 어린 무지개송어의 충혈 혈관 수를 증가시켰다[4]. Bifenthrin(8mg/kg; 7일; 복강내 투여)은 일부 BALB/c 쥐 표본의 간 조직에서 국소 핵 응축 및 공포 변성을 유도하였다; Bifenthrin(2, 4, 8mg/kg; 7일; 복강내 투여)은 BALB/c 쥐의 미토콘드리아 ROS 생성을 용량 의존적으로 증가시켰다[5]. Bifenthrin(0.6mg/kg; 6주; 격일; 위내 투여)은 C57BL/6 쥐의 체중을 현저하게 증가시켰다; Bifenthrin(0.6mg/kg; 6주; 격일; 위내 투여)은 C57BL/6 쥐의 HSL 및 ATGL 발현을 현저하게 하향 조절하고 LPL 발현을 현저하게 상향 조절하였다[6].
References:
[1] Moreira C V L, Ogbu J s, Monteiro K L C, et al. Bifenthrin under scrutiny: revisiting toxicological evidence amid regulatory gaps [J]. Journal of applied toxicology : JAT, 2026, 46(1): 61-77.
[2] Mukhtar F, Jilani K, Bibi I, et al. Stimulation of erythrocyte membrane blebbing by Bifenthrin induced oxidative stress [J]. Dose-response : a publication of International Hormesis Society, 2022, 20(1): 15593258221076710.
[3] Gargouri B, Yousif N M, Bouchard M, et al. Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures [J]. Journal of neuroinflammation, 2018, 15(1): 159.
[4] Magnuson J T, Caceres L, Sy N, et al. The use of non-targeted lipidomics and histopathology to characterize the neurotoxicity of Bifenthrin to juvenile rainbow trout (Oncorhynchus mykiss) [J]. Environmental science & technology, 2022, 56(16): 11482-11492.
[5] Zhang Y, Lu M, Zhou P, et al. Multilevel evaluations of potential liver injury of bifenthrin [J]. Pesticide biochemistry and physiology, 2015, 122: 29-37.
[6] Wei C, Wang X, Yao X, et al. Bifenthrin induces fat deposition by improving fatty acid uptake and inhibiting lipolysis in mice [J]. Journal of agricultural and food chemistry, 2019, 67(51): 14048-14055.
| 세포 실험 [1]: | |
세포 라인 | 쥐의 1차 미세아교세포 |
제조 방법 | 미세아교세포를 Bifenthrin(DMSO를 대조 그룹으로)에 24시간 노출시켰습니다. TNF-알파와 IL-6의 유전자 발현은 실시간 정량 PCR로 분석하였습니다. |
반응 조건 | 20μM; 24시간 동안 |
응용 분야 | Bifenthrin은 1차 미세아교세포에서 IL-6 및 TNF-알파 mRNA 발현을 증가시켰습니다. |
| 동물 실험 [2]: | |
동물 모형 | BALB/c 쥐 |
제조 방법 | 동물들은 옥수수 기름에 적절한 농도로 배합된 Bifenthrin을 0.3 mL 복강내 주사해서 매일 노출되었습니다. 7일간의 처리기간이 끝난 후 간은 분석을 위해 채취되었습니다. |
제형 | 2, 4, 8mg/kg; 7일 동안; i.p. |
응용 분야 | Bifenthrin은 미토콘드리아 ROS 생성을 용량 의존적으로 증가시켰습니다. |
References: | |
| Cas No. | 82657-04-3 | SDF | |
| Synonyms | (±)-Bifenthrin | ||
| Canonical SMILES | O=C([C@H]1C(C)(C)[C@H]1/C=C(Cl)/C(F)(F)F)OCC2=C(C)C(C3=CC=CC=C3)=CC=C2 | ||
| Formula | C23H22ClF3O2 | M.Wt | 422.87 |
| Solubility | DMSO: 100 mg/mL (236.48 mM) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3648 mL | 11.824 mL | 23.6479 mL |
| 5 mM | 473 μL | 2.3648 mL | 4.7296 mL |
| 10 mM | 236.5 μL | 1.1824 mL | 2.3648 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)