ent-8-iso-15(S)-Prostaglandin F2α (Synonyms: ent-15-epi-F2t-Isoprostane, ent-8-iso-15-epi-PGF2α) |
| カタログ番号GC40590 |
イソプロスタンは、ホスフォリピッドエステル化されたアラキドン酸の非酵素的なフリーラジカル過酸化によって生成されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 214748-66-0
Sample solution is provided at 25 µL, 10mM.
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Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2α (ent-8-iso-15(S)-PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively. This isoprostane is about ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation inhibition assay.
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