10β,17β-dihydroxyestra-1,4-dien-3-one (Synonyms: DHED) |
| Catalog No.GC38542 |
10β,17β-dihydroxyestra-1,4-dien-3-one(DHED)은 주요 인간 에스트로겐의 뇌 표적 생물전구체 전구약물입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 549-02-0
Sample solution is provided at 25 µL, 10mM.
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10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1].
[1]. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.
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