Metabolism

TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM).

viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50s = 34 and 83 nM for the human and mouse enzymes, respectively).

Etomidate-d5 is intended for use as an internal standard for the quantification of etomidate by GC- or LC-MS.

ABBV-CLS-484 is a dual inhibitor of protein tyrosine phosphatase 1N (PTP1N) and PTP2N (IC50s = 2.5 and 1.8 nM, respectively).

ENPP3 inhibitor 5J is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) and ENPP3 (IC50s = 0.59 and 0.62 µM, respectively, for the human enzymes).

GSK205 is an inhibitor of transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential ankyrin 1 (TRPA1; IC50s = 4.19 and 5.56 µM, respectively, for the rat channels).

18-hydroxy Oleoyl leucine-d7 is intended for use as an internal standard for the quantification of 18-hydroxy oleoyl leucine by GC- or LC-MS.

h-e5'NT Inhibitor 5C is an inhibitor of ecto-5'-nucleotidase, also known as CD73 (IC50s = 0.37 and 1.66 µM for the human and rat enzymes, respectively).

FA16 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.

Cholic acid 3-sulfate is a metabolite of the primary bile acid cholic acid .

Ferroptosis inhibitor D1 is a free radical scavenger and an inhibitor of ferroptosis.

Rhein-13C6 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS.

E17241 is an inducer of the expression of ABCA1, the gene encoding ATP-binding cassette transporter 1; subfamily A (ABCA1).

ECSI#6 is an inhibitor of the serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET).

Ppc-1 is a prenylated quinolinecarboxylic acid originally isolated from P. pseudo-candidum that has diverse biological activities.

GAPDH inhibitor compound F8 is a covalent inhibitor of GAPDH (IC50 = 39.31 μM).

TrkB agonist prodrug R13 (R13) is a prodrug form of the tropomyosin-related kinase B (TrkB) activator 7,8-dihydroxyflavone.

Pantothenate-AMC is a fluorogenic substrate for vanin-1, an enzyme involved in the recycling of L-pantothenic acid.

N-Lithocholyl-L-leucine is a bile acid conjugate composed of lithocholic acid and L-leucine.

GPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis.

HPG1860 is a farnesoid X receptor (FXR) agonist.

Glucagon-like peptide 1 (GLP-1) (28-36) amide is a peptide and an active metabolite of the endogenous GLP-1R agonist GLP-1 (7-36) amide.

KISS1-305 is a peptide agonist of the kisspeptin receptor.

TCMCB07 is a peptide antagonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (IC50s = 19.5, 0.59, 13.58, and 8.07 nM, respectively, for the human receptors).