PDK-1
PDK-1 (3-phosphoinositide dependent protein kinase-1) is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK.
Products for PDK-1
- Cat.No. Product Name Information
- GC63802 (R)-PS210 (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment.
- GC16818 BX-912 PDK1 inhibitor,potent and ATP-competitive
- GC15615 BX517(PDK1 inhibitor2) BX517(PDK1 inhibitor2) is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
- GC11573 BX795 A multi-kinase inhibitor
- GC12275 GSK2334470 PDK1 inhibitor,highly specific and potent
- GC13725 NVP-BAG956 A dual PDK1 and class I PI3K inhibitor
- GC15742 OSU-03012 (AR-12) Potent PDK1 inhibitor
- GC12866 PDK1 inhibitor
- GC66474 PDK1-IN-RS2 PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.
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GC69714
PKD-IN-1 dihydrochloride
PKD-IN-1 dihydrochloride (compound 32) is an aminoethylaminobenzyl (AEAA) compound that can be used as a PKD-1 inhibitor. PKD-IN-1 can be used in research on diseases mediated by protein kinase D (PKD).
- GN10709 Polyphyllin A
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GC13920
PS 48
PDK1 activator
- GC63155 PS47 PS47 is an inactive E-isomer of PS48.
- GC10857 UCN-01 inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinases