The immune and inflammation-related pathway including the Toll-like receptors pathway, the B cell receptor signaling pathway, the T cell receptor signaling pathway, etc.
Toll-like receptors (TLRs) play a central role in host cell recognition and responses to microbial pathogens. TLR4 initially recruits TIRAP and MyD88. MyD88 then recruits IRAKs, TRAF6, and the TAK1 complex, leading to early-stage activation of NF-κB and MAP kinases . TLR4 is endocytosed and delivered to intracellular vesicles and forms a complex with TRAM and TRIF, which then recruits TRAF3 and the protein kinases TBK1 and IKKi. TBK1 and IKKi catalyze the phosphorylation of IRF3, leading to the expression of type I IFN .
BCR signaling is initiated through ligation of mIg under conditions that induce phosphorylation of the ITAMs in CD79, leading to the activation of Syk. Once Syk is activated, the BCR signal is transmitted via a series of proteins associated with the adaptor protein B-cell linker (Blnk, SLP-65). Blnk binds CD79a via non-ITAM tyrosines and is phosphorylated by Syk. Phospho-Blnk acts as a scaffold for the assembly of the other components, including Bruton’s tyrosine kinase (Btk), Vav 1, and phospholipase C-gamma 2 (PLCγ2) . Following the assembly of the BCR-signalosome, GRB2 binds and activates the Ras-guanine exchange factor SOS, which in turn activates the small GTPase RAS. The original RAS signal is transmitted and amplified through the mitogen-activated protein kinase (MAPK) pathway, which including the serine/threonine-specific protein kinase RAF followed by MEK and extracellular signal related kinases ERK 1 and 2 . After stimulation of BCR, CD19 is phosphorylated by Lyn. Phosphorylated CD19 activates PI3K by binding to the p85 subunit of PI3K and produce phosphatidylinositol-3,4,5-trisphosphate (PIP3) from PIP2, and PIP3 transmits signals downstream .
Central process of T cells responding to specific antigens is the binding of the T-cell receptor (TCR) to specific peptides bound to the major histocompatibility complex which expressed on antigen-presenting cells (APCs). Once TCR connected with its ligand, the ζ-chain–associated protein kinase 70 molecules (Zap-70) are recruited to the TCR-CD3 site and activated, resulting in an initiation of several signaling cascades. Once stimulation, Zap-70 forms complexes with several molecules including SLP-76; and a sequential protein kinase cascade is initiated, consisting of MAP kinase kinase kinase (MAP3K), MAP kinase kinase (MAPKK), and MAP kinase (MAPK) . Two MAPK kinases, MKK4 and MKK7, have been reported to be the primary activators of JNK. MKK3, MKK4, and MKK6 are activators of P38 MAP kinase . MAP kinase pathways are major pathways induced by TCR stimulation, and they play a key role in T-cell responses.
Phosphoinositide 3-kinase (PI3K) binds to the cytosolic domain of CD28, leading to conversion of PIP2 to PIP3, activation of PKB (Akt) and phosphoinositide-dependent kinase 1 (PDK1), and subsequent signaling transduction .
 Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors[J]. Nature immunology, 2010, 11(5): 373-384.
 Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity[J]. Immunity, 2011, 34(5): 637-650.
 Packard T A, Cambier J C. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation[J]. F1000Prime Rep, 2013, 5(40.10): 12703.
 Zhong Y, Byrd J C, Dubovsky J A. The B-cell receptor pathway: a critical component of healthy and malignant immune biology[C]//Seminars in hematology. WB Saunders, 2014, 51(3): 206-218.
 Baba Y, Matsumoto M, Kurosaki T. Calcium signaling in B cells: regulation of cytosolic Ca 2+ increase and its sensor molecules, STIM1 and STIM2[J]. Molecular immunology, 2014, 62(2): 339-343.
 Adachi K, Davis M M. T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells[J]. Proceedings of the National Academy of Sciences, 2011, 108(4): 1549-1554.
 Rincón M, Flavell R A, Davis R A. The Jnk and P38 MAP kinase signaling pathways in T cell–mediated immune responses[J]. Free Radical Biology and Medicine, 2000, 28(9): 1328-1337.
 Bashour K T, Gondarenko A, Chen H, et al. CD28 and CD3 have complementary roles in T-cell traction forces[J]. Proceedings of the National Academy of Sciences, 2014, 111(6): 2241-2246.
Targets for Immunology/Inflammation
- Cyclic GMP-AMP Synthase(1)
- PGE synthase(23)
- Interleukin Related(81)
- Aryl Hydrocarbon Receptor(28)
- Complement System(34)
- NO Synthase(63)
- NOD-like Receptor (NLR)(28)
- Reactive Oxygen Species(363)
- Adaptive Immunity(133)
- Gastric Disease(57)
- Innate Immunity(375)
- Pulmonary Diseases(63)
- Reactive Nitrogen Species(43)
- Specialized Pro-Resolving Mediators(41)
- Reactive Sulfur Species(24)
Products for Immunology/Inflammation
- Cat.No. Product Name Information
NLRP3 inflammasome inhibitor
Bacteria synthesize the cellular growth factor putrescine through a number of pathways.
- GC65446 α-Amyrin acetate
α-GalCer analog 8
α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.
- GC40262 α-Humulene α-Humulene is a sesquiterpene that has been found in C.
- GC45601 α-Linolenic Acid ethyl ester-d5
- GC41499 α-Phellandrene α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities.
- GC63941 α-Solanine
- GC49467 β-Aescin A triterpenoid saponin with diverse biological activities
- GC45225 β-Apooxytetracycline β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline.
- GC45230 β-Defensin-3 (human) (trifluoroacetate salt) β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
- GC45231 β-Defensin-4 (human) (trifluoroacetate salt) β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
- GC41623 β-Elemonic Acid β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity.
- GC64619 β-Ionone
- GC41502 β-Myrcene β-Myrcene is a terpene that has been found in Cannabis and has antioxidative properties.
- GC45604 β-Rubromycin
- GC40790 γ-Linolenic Acid ethyl ester γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis.
- GC45238 δ14-Triamcinolone acetonide δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide.
- GC40307 δ2-cis-Hexadecenoic Acid One of the first organisms in which quorum sensing was observed were Myxobacteria, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems.
- GC41393 ω-3 Arachidonic Acid methyl ester ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development.
- GC45713 (±)-α-Tocopherol Acetate
- GC52010 (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid An oxylipin gut microbiota metabolite
- GC52013 (±)-10-hydroxy-12(Z)-Octadecenoic Acid An oxylipin and metabolite of linoleic acid
- GC40112 (±)-Climbazole-d4 (±)-Climbazole-d4 is intended for use as an internal standard for the quantification of climbazole by GC- or LC-MS.
- GC50708 (±)-ML 209
- GC39271 (±)-Naringenin
- GC41212 (±)10(11)-EpDPA Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers.
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.
- GC40467 (±)11-HETE (±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
- GC41191 (±)13(14)-EpDPA Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers.
(±)13-HpODE is a racemic mixture of hydroperoxides derived non-enzymatically from linoleic acid through the action of reactive oxygen species.
- GC41288 (±)17(18)-EpETE-Ethanolamide (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide.
- GC40362 (±)18-HEPE (±)18-HEPE is produced by non-enzymatic oxidation of EPA.
- GC41655 (±)19(20)-EDP Ethanolamide (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively).
5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.
- GC41203 (±)7(8)-EpDPA Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina.
- GC40801 (±)9(10)-DiHOME Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst.
- GC46000 (•)-Drimenol
- GC40809 (+)-β-Citronellol (+)-β-Citronellol is a monoterpene that has been found in Cannabis.
- GN10654 (+)-Corynoline Extracted from corydalis sheareri S. Moore;Store the product in sealed,cool and dry condition
- GC45263 (+)-D-threo-PDMP (hydrochloride) (+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP.
- GC31691 (+)-DHMEQ ((1R,2R,6R)-Dehydroxymethylepoxyquinomicin)
- GC45266 (+)-Macrosphelide A (+)-Macrosphelide A is a fungal metabolite originally isolated from Microsphaeropsis.
- GC40266 (+)-Praeruptorin A (+)-Praeruptorin A is a coumarin derivative originally isolated from P.
- GC18749 (+)-Rugulosin (+)-Rugulosin is a pigment and mycotoxin produced by certain fungi.
- GC63969 (+)-Schisandrin B
(+)-Valencene is a sesquiterpene that has been found in C.
- GC49502 (-)-β-Sesquiphellandrene A sesquiterpene with antiviral and anticancer activities
- GC32705 (-)-DHMEQ (Dehydroxymethylepoxyquinomicin)
- GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent
- GC45248 (-)-FINO2 (-)-FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron.
- GC38316 (-)-Limonene
- GC45251 (-)-Neplanocin A S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine.
- GC45272 (-)-Rasfonin
- GC40803 (25S)-δ7-Dafachronic Acid During unfavorable environmental conditions, C.
- GC41700 (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities.
- GC61668 (E)-3,4-Dimethoxycinnamic acid
- GC41702 (E)-5-(2-Bromovinyl)uracil (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo.
- GC41703 (E)-C-HDMAPP (ammonium salt) Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes.
- GC39747 (E/Z)-GSK5182
- GC61564 (E/Z)-IT-603
- GC41721 (R)-α-Lipoic Acid (R)-α-Lipoic acid is the naturally occurring enantiomer of lipoic acid, a cyclic disulfide antioxidant.
- GC13030 (R)-(-)-Ibuprofen Inhibitor of Cox-1 and Cox-2
- GC41620 (R)-(-)-Mellein (R)-(-)-Mellein is a dihydroisocoumarin compound produced by A.
- GC41712 (R)-3-hydroxy Myristic Acid Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria.
- GC65610 (R)-5-Hydroxy-1,7-diphenyl-3-heptanone
- GC65373 (R)-IL-17 modulator 4
- GC12578 (R)-Lisofylline anti-inflammatory agent
- GC52185 (R,S)-Anatabine-d4
- GC39321 (Rac)-Myrislignan
- GC52192 (S)-4'-nitro-Blebbistatin
- GC11867 (S)-Lisofylline inactive optical enantiomer of (R)-LSF, an anti-inflammatory agent
- GC13427 (S)-Methylisothiourea sulfate iNOS inhibitor
- GC41740 (S)-p38 MAPK Inhibitor III (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).
- GC38880 (Z)-Leukadherin-1
- GC18787 (±)-Dunnione (±)-Dunnione is a naturally occurring naphthoquinone with diverse biological activities.
- GC13662 (±)-Lisofylline anti-inflammatory agent
- GC46054 1β-Acetoxypolygodial
- GC45285 1,2,3-Trihexanoyl-rac-glycerol
- GC46042 1,2-Dipalmitoyl-13C-sn-glycero-3-PC
- GC45781 1,2-Dipalmitoyl-d31-sn-glycero-3-PC
1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.
- GC35037 1,3-Dicaffeoylquinic acid
- GC41855 1,3-Distearoyl-2-Oleoyl-rac-glycerol 1,3-Distearoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains stearic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position.
- GC11173 1,3-PBIT (dihydrobromide) potent inhibitor of iNOS
- GC33314 1,4-Chrysenequinone (Chrysene-1,4-dione)
- GC14627 1,4-PBIT (dihydrobromide) potent inhibitor of purified human iNOS and nNOS
- GC40706 1,6-Dimethoxyphenazine 1,6-Dimethoxyphenazine is a bacterial metabolite that has been found in S.
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position.
- GC41990 1-Decanoyl-rac-glycerol 1-Decanoyl-rac-glycerol is a monoacylglycerol that contains decanoic acid at the sn-1 position.
- GC52186 1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC
- GC45957 1-Heptadecanoyl-rac-glycerol
- GC49495 1-Isothiocyanato-6-(methylsulfenyl)-hexane An isothiocyanate with diverse biological activities
- GC45696 1-Lauroyl-rac-glycerol
- GC41998 1-Methyl-4-imidazoleacetic Acid (hydrochloride) 1-Methyl-4-imidazoleacetic acid (MIMA) is a stable metabolite of histamine that is produced by the oxidation of the primary metabolite, N-methylhistamine.
- GC13379 1-Naphthyl 3,5-dinitrobenzoate dual 5-lipoxygenase and microsomal prostaglandin E synthase-1 inhibitor
1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether.
- GC42010 1-Octanoyl-rac-glycerol 1-Octanoyl-rac-glycerol is a monoacylglycerol that contains octanoic acid at the sn-1 position.
- GC40910 1-Oleoyl-2-hydroxy-sn-glycero-3-PE 1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine.