1-Palmitoyl-2-hydroxy-sn-glycero-3-PE-d9

1-Palmitoyl-2-hydroxy-sn-glycero-3-PE-d9 is intended for use as an internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PE by GC- or LC-MS. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid.1 It inhibits the growth of L. donovani promastigotes (GI50 = 8 μM).2 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE serum levels are decreased in a mouse model of alcohol-induced liver injury and in a hepatocellular carcinoma mouse xenograft model.3 Human serum levels are also decreased immediately and 14 hours following an exercise regimen of 2.5 hours of running for three days.1 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE has been used as an internal standard for the quantification of saturated lysophosphoethanolamines.4

|1. Nieman, D.C., Shanely, R.A., Gillitt, N.D., et al. Serum metabolic signatures induced by a three-day intensified exercise period persist after 14 h of recovery in runners. J. Proteome Res. 12(10), 4577-4584 (2013).|2. Achterberg, V., and Gercken, G. Cytotoxicity of ester and ether lysophospholipids on Leishmania donovani promastigotes. Mol. Biochem. Parasitol. 23(2), 117-122 (1987).|3. Li, S., Liu, H., Jin, Y., et al. Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879(24), 2369-2375 (2011).|4. Avadhani, M., Geyer, R., White, D.C., et al. Lysophosphatidylethanolamine is a substrate for the short-chain alcohol dehydrogenase SocA from Myxococcus xanthus. J. Bacteriol. 188(24), 8543-8550 (2006).