1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PE (Synonyms: 1-Hexadecanoyl-d9-sn-glycero-3-Phosphoethanolamine, 16:0 LPE-d9, 16:0 Lyso-PE-d9, 1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-Phosphoethanolamine)

1-Palmitoyl-d₉-2-hydroxy-sn-glycero-3-PE is intended for use as an internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PE by GC- or LC-MS. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid.¹ It inhibits the growth of L. donovani promastigotes (GI₅₀ = 8 µM).² 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE serum levels are decreased in a mouse model of alcohol-induced liver injury and in a hepatocellular carcinoma mouse xenograft model.³ Human serum levels are also decreased immediately and 14 hours following an exercise regimen of 2.5 hours of running for three days.¹ 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE has been used as an internal standard for the quantification of saturated lysophosphoethanolamines.⁴

1.Nieman, D.C., Shanely, R.A., Gillitt, N.D., et al.Serum metabolic signatures induced by a three-day intensified exercise period persist after 14 h of recovery in runnersJ. Proteome Res.12(10)4577-4584(2013) 2.Achterberg, V., and Gercken, G.Cytotoxicity of ester and ether lysophospholipids on Leishmania donovani promastigotesMol. Biochem. Parasitol.23(2)117-122(1987) 3.Li, S., Liu, H., Jin, Y., et al.Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in miceJ. Chromatogr. B Analyt. Technol. Biomed. Life Sci.879(24)2369-2375(2011) 4.Avadhani, M., Geyer, R., White, D.C., et al.Lysophosphatidylethanolamine is a substrate for the short-chain alcohol dehydrogenase SocA from Myxococcus xanthusJ. Bacteriol.188(24)8543-8550(2006)