10Panx (trifluoroacetate salt) (Synonyms: 10Panx1, WRQAAFVDSY) |
| Catalog No.GC52423 |
A peptide inhibitor of PANX1
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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10Panx is a peptide mimetic of the pannexin 1 (PANX1) ectodomain and inhibitor of PANX1, an innexin family gap domain protein and component of membrane channels.1 It inhibits purinergic P2X7 receptor activation-induced dye uptake, constitutive dye uptake, and hemichannel currents, as well as ATP-induced caspase activation and IL-1β release in HEK293 cells when used at a concentration of 200 µM. 10Panx inhibits pannexin channel currents and connexin 46 channel currents in Xenopus oocytes expressing the human channels.2
1.Pelegrin, P., and Surprenant, A.Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptorEMBO J.25(21)5071-5082(2006) 2.Wang, J., Ma, M., Locovei, S., et al.Modulation of membrane channel currents by gap junction protein mimetic peptides: Size mattersAm. J. Physiol. Cell Physiol.293(3)C1112-C1119(2007)
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