113-O12B |
| Catalog No.GC52343 |
An ionizable cationic lipidoid
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2803699-72-9
Sample solution is provided at 25 µL, 10mM.
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113-O12B is a disulfide bond-containing ionizable cationic lipidoid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing 113-O12B and encapsulating mRNA encoding ovalbumin reduce tumor growth and increase the number of tumoral CD8+ T cells, M1-like macrophages, and activated dendritic cells in an ovalbumin-expressing B16/F10 murine melanoma model.
1.Chen, J., Ye, Z., Huang, C., et al.Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell responseProc. Natl. Acad. Sci. USA119(34)e2207841119(2022)
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