12(S)-HETE-d8 (Synonyms: 12(S)-Hydroxyeicosatetraenoic Acid-d8)

12(S)-HETE-d₈ contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. It is intended for use as an internal standard for the quantification of 12(S)-HETE by GC- or LC-mass spectrometry (MS). 12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.¹ It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.^2,3

1.Hamberg, M., and Samuelsson, B.Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human plateletsProc. Natl. Acad. Sci. U.S.A.71(9)3400-3404(1974) 2.Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al.Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acidCancer Res.49(4)1029-1037(1989) 3.Honn, K.V., Nelson, K.K., Renaud, C., et al.Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasisProstaglandins44(5)413-429(1992)