(±)11-HETE-d8 (Synonyms: (±)11-Hydroxyeicosatetraenoic Acid-d8)

(±)11-HETE-d₈ is intended for use as an internal standard for the quantification of (±)11-HETE by GC- or LC-MS. (±)11-HETE is an oxylipin formed non-enzymatically from arachidonic acid .^1,2 Levels of (±)11-HETE are increased in an in vitro model of lipid peroxidation induced by ferrous ammonium sulfate (FAS) in rat brain homogenates.³ Levels are also increased in rat liver in an in vivo model of lipid peroxidation induced by carbon tetrachloride (CCl₄). It has been found in skin extracts from individuals with psoriasis and in atherosclerotic plaques.^4,5

1.Powell, W.S., and Rokach, J.Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acidBiochim. Biophys. Acta1851(4)340-355(2014) 2.Derogis, P.B.M.C., Chaves-Filho, A.B., and Miyamoto, S.Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometryBioactive lipids in health and disease21-38(2019) 3.Guido, D.M., McKenna, R., and Mathews, W.R.Quantitation of hydroperoxy-eicosatetraenoic acids and hydroxy-eicosatetraenoic acids as indicators of lipid peroxidation using gas chromatography-mass spectrometryAnal. Biochem.209(1)123-129(1993) 4.Camp, R.D.R., Mallet, A.I., Woollard, P.M., et al.The identification of hydroxy fatty acids in psoriatic skinProstaglandins26(3)431-447(1983) 5.Waddington, E., Sienuarine, K., Puddey, I., et al.Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatographyAnal. Biochem.292(2)234-244(2001)