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2,3-Diphosphoglyceric acid pentasodium

Catalog No.GC70354 Copy One-Click Copy Product Info

2,3-Diphosphoglyceric acid (2,3-DPG) pentasodium is an intermediate of the glycolytic pathway.

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2,3-Diphosphoglyceric acid pentasodium Chemical Structure

Cas No.: 1287756-01-7

Size Price Stock Qty
5 mg
$135.00
In stock
10 mg
$225.00
In stock
25 mg
$495.00
In stock
50 mg
$765.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of 2,3-Diphosphoglyceric acid pentasodium

2,3-Diphosphoglyceric acid (2,3-DPG) pentasodium is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid pentasodium stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2,3-Diphosphoglyceric acid pentasodium binds to hemoglobin and decrease its affinity for oxygen.

References:
[1]. Shakil H. Merchant MD, et al. 24 - Molecular Diagnosis in Hematopathology. Hematopathology (Second Edition).2012, 679-726.
[2]. Płoszczyca K, et al. Red Blood Cell 2,3-Diphosphoglycerate Decreases in Response to a 30 km Time Trial Under Hypoxia in Cyclists. Front Physiol. 2021 Jun 15;12:670977.

Chemical Properties of 2,3-Diphosphoglyceric acid pentasodium

Cas No. 1287756-01-7 SDF
Formula C3H3Na5O10P2 M.Wt 375.95
Solubility H2O : 250 mg/mL (664.98 mM; Need ultrasonic); DMSO : < 1 mg/mL (insoluble or slightly soluble) Storage -20°C, stored under nitrogen, away from moisture
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 2,3-Diphosphoglyceric acid pentasodium

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.6599 mL 13.2996 mL 26.5993 mL
5 mM 532 μL 2.6599 mL 5.3199 mL
10 mM 266 μL 1.33 mL 2.6599 mL
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

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In vivo Formulation Calculator (Clear solution) of 2,3-Diphosphoglyceric acid pentasodium

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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