7-(β-Hydroxyethyl)theophylline-d6 (Synonyms: Etophylline-d6, Hydroxyethyltheophylline-d6) |
| Catalog No.GC49887 |
An internal standard for the quantification of 7-(β-hydroxyethyl)theophylline
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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7-(β-Hydroxyethyl)theophylline-d6 is intended for use as an internal standard for the quantification of 7-(β-hydroxyethyl)theophylline by GC- or LC-MS. 7-(β-Hydroxyethyl)theophylline is a methylxanthine phosphodiesterase (PDE) inhibitor.1 It reduces histamine, 5-hydroxytryptamine (5-HT), and bradykinin-induced bronchoconstriction in an anesthetized guinea pig model of bronchial asthma.2 Formulations containing 7-(β-hydroxyethyl)theophylline in combination with theophylline have been used in the treatment of asthma.
1.Mizon, J., Skandrani, E., and Mizon, C.Determination of the inhibitory activity of some new substituted theophyllines on the specific phosphodiesterase of cyclic nucleotidesTherapie26(5)911-917(1971) 2.Ufkes, J.G., Leeuwin, R.S., Ottenhof, M., et al.Efficacy of theophylline and its N-7-substituted derivatives in experimentally induced bronchial asthma in the guinea-pigArch. Int. Pharmacodyn. Ther.253(2)301-314(1981)
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