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Aerothionin

Catalog No.GC15759

antimycobacterial activity

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Aerothionin Chemical Structure

Cas No.: 28714-26-3

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1mg
$215.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

IC50: 29 μM for HeLa cells proliferation

Aerothionin is derived from marine sponges with an antimycobacterial activity.

Antimycobacterial drugs are used in the treatment of diseases caused by Mycobacterium genus, such as tuberculosis and leprosy.

In vitro: In a continuation of efforts to identify bioactive compounds from Red Sea Verongid sponges, the organic extract of the sponge Suberea species afforded seven compounds including aerothionin, together with two new dibrominated alkaloids and four known compounds. In-vitro cytotoxicity study showed that aerothionin and subereaphenol C had potent cytotoxic activity against HeLa cell line with IC50 values of 29 and 13.3 μM, respectively. [1].

In vivo: Red Sea Suberea mollis sponge extract (SMSE), which contains aerothionin, was evaluated for its protective effect on carbon tetrachloride- (CCl4-) induced acute liver injury in rats. Rats were orally administered three different concentrations of SMSE along with CCl4 for 14 days. SMSE could significantly reduce liver enzyme activities and hepatic MDA formation. In addition, SMSE was able to restore NO, SOD, GSH, GPx, and CAT. The histopathological results further confirmed these in-vivo findings [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Shaala, L. A.,Youssef, D.T.A.,Badr, J.M., et al. Bioactive secondary metabolites from the read sea marine verongid sponge Suberea species. Mar.Drugs 13, 1621-1631 (2015).
[2] Abbas AT, El-Shitany NA, Shaala LA, Ali SS, Azhar EI, Abdel-Dayem UA, Youssef DT. Red Sea Suberea mollis Sponge Extract Protects against CCl4-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism. Evid Based Complement Alternat Med. 2014;2014:745606.

Chemical Properties

Cas No. 28714-26-3 SDF
Chemical Name (5S,5'S,10R,10'R)-N,N'-1,4-butanediylbis[7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide
Canonical SMILES O=C(NCCCCNC(C1=NO[C@@]2([C@@H](O)C(Br)=C(OC)C(Br)=C2)C1)=O)C3=NO[C@@]4([C@@H](O)C(Br)=C(OC)C(Br)=C4)C3
Formula C24H26Br4N4O8 M.Wt 818.1
Solubility Soluble in ethanol;Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.2223 mL 6.1117 mL 12.2234 mL
5 mM 0.2445 mL 1.2223 mL 2.4447 mL
10 mM 0.1222 mL 0.6112 mL 1.2223 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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