Home>>AGN-201904

AGN-201904 (Synonyms: AGN 201904; AGN201904; AGN-201904)

Catalog No.GB62306 Copy One-Click Copy Product Info

AGN 201904 is a slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time.

Products are for research use only. Not for human use. We do not sell to patients.

AGN-201904 Chemical Structure

Cas No.: 651729-53-2

Size Price Stock Qty
1mg
$150.00
In stock
5mg
$250.00
In stock
10mg
$450.00
In stock
25mg
$750.00
In stock
50mg
$1,350.00
In stock
100mg
$2,350.00
In stock

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Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of AGN-201904

AGN 201904 is a slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time. AGN-201904 is a proton pump inhibitor; AGN-201904-Z is the sodium salt; AGN-201904 is an omeprazole prodrug. AGN 201904 produced a significantly greater and more prolonged acid suppression than esomeprazole, and nocturnal acid suppression was more prolonged over all 5 days. AGN 201904 should provide true once-a-day treatment and better clinical efficacy than current PPIs.

Chemical Properties of AGN-201904

Cas No. 651729-53-2 SDF
Synonyms AGN 201904; AGN201904; AGN-201904
Canonical SMILES O=C(O)COC1=CC=C(S(=O)(N2C3=CC=C(OC)C=C3N=C2S(CC4=NC=C(C)C(OC)=C4C)=O)=O)C=C1
Formula C25H25N3O8S2 M.Wt 559.608
Solubility Soluble in DMSO Storage Store at-20℃
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of AGN-201904

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.787 mL 8.9348 mL 17.8697 mL
5 mM 357.4 μL 1.787 mL 3.5739 mL
10 mM 178.7 μL 893.5 μL 1.787 mL
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In vivo Formulation Calculator (Clear solution) of AGN-201904

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Reviews

Review for AGN-201904

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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