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Arsthinol (Synonyms: Arsthinenol; Arsthinol; Balarsen; Mercaptoarsenol;)

Catalog No.GB62282 Copy One-Click Copy Product Info

Arsthinol is an antiprotozoal agent which may have anti-cancer activity.

Products are for research use only. Not for human use. We do not sell to patients.

Arsthinol Chemical Structure

Cas No.: 119-96-0

Size Price Stock Qty
1mg
$85.00
In stock
5mg
$150.00
In stock
10mg
$250.00
In stock
25mg
$550.00
In stock
50mg
$950.00
In stock
100mg
$1,650.00
In stock
200mg
$2,950.00
In stock

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Customer Reviews

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Sample solution is provided at 25 µL, 10mM.



Description of Arsthinol

Arsthinol is an antiprotozoal agent which may have anti-cancer activity. It was found that arsthinol, a trivalent organoarsenic compound (dithiarsolane), has been active in vitro on leukemia cell lines and offers a better therapeutic index than arsenic trioxide, as estimated by the ratio LD50/IC50. Arsthinol induced growth inhibition of NB4 cells at lower concentration (IC50 (concentration inhibiting growth by 50%) = 0.78 +/- 0.08 micromol/l after 24 h) than As(2)O(3) (IC50 = 1.60 +/- 0.23 micromol/l after 24 h) or melarsoprol (IC50 = 1.44 +/- 0.08 micromol/l after 24 h). Arsthinol-cyclodextrin complex demonstrated to have was more effective than arsenic trioxide (As2O3) and melarsoprol on the U87 MG cell line. Importantly, in the in vivo study, significant antitumor activity against heterotopic xenografts was observed after i.p. administration.

Chemical Properties of Arsthinol

Cas No. 119-96-0 SDF
Synonyms Arsthinenol; Arsthinol; Balarsen; Mercaptoarsenol;
Canonical SMILES OC1=CC=C([As](S2)SCC2CO)C=C1NC(C)=O
Formula C11H14AsNO3S2 M.Wt 347.28
Solubility Soluble in DMSO Storage Store at-20℃
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Arsthinol

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.8795 mL 14.3976 mL 28.7952 mL
5 mM 575.9 μL 2.8795 mL 5.759 mL
10 mM 288 μL 1.4398 mL 2.8795 mL
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In vivo Formulation Calculator (Clear solution) of Arsthinol

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Reviews

Review for Arsthinol

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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