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BAY 57-1293-d4 (Synonyms: Pritelivir-d4)

Catalog No.GC91407 Copy One-Click Copy Product Info

BAY 57-1293-d4 is intended for use as an internal standard for the quantification of BAY 57-1293 by GC- or LC-MS.

Products are for research use only. Not for human use. We do not sell to patients.

BAY 57-1293-d4 Chemical Structure

Size Price Stock Qty
500μg
$216.00
In stock
1mg
$388.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of BAY 57-1293-d4

BAY 57-1293-d4 is intended for use as an internal standard for the quantification of BAY 57-1293 by GC- or LC-MS. BAY 57-1293 is an orally bioavailable helicase-primase inhibitor.1 It inhibits the ATPase activity of herpes simplex virus (HSV) helicase-primase (IC50 = 30 nM). It inhibits HSV replication in Vero cells (IC50 = 20 nM for both HSV-1 and HSV-2) and is also active against porcine and bovine HSV strains (IC50s = 5 and 0.12 μM, respectively). In vivo, oral administration of BAY 57-1293 is effective against HSV-1 and HSV-2 in a lethal challenge model (ED50 = 0.5 mg/kg in mice and rats) and in a zosteriform spread model, at a dose of 15 mg/kg, in mice and Lewis rats.1,2 It is also effective in a guinea pig model of genital herpes and a mouse model of ocular herpes. BAY 57-1293 reduces levels of amyloid-beta (Aβ) and phosphorylated Tau in HSV-1 infected Vero cells.3

Chemical Properties of BAY 57-1293-d4

Cas No. SDF
Synonyms Pritelivir-d4
Formula C18H14D4N4O3S2 M.Wt 406.5
Solubility Chloroform: Soluble,DMSO: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of BAY 57-1293-d4

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1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3001 mL 24.6002 mL
5 mM 492 μL 2.46 mL 4.92 mL
10 mM 246 μL 1.23 mL 2.46 mL
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In vivo Formulation Calculator (Clear solution) of BAY 57-1293-d4

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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