BMP-22 |
| Catalog No.GC42951 |
BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1306684-90-1
Sample solution is provided at 25 µL, 10mM.
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BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.
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