C16 Sphingomyelin (d18:1/16:0) (Synonyms: Palmitoyl Sphingomyelin, N-Palmitoyl-D-erythro-Sphingosylphosphorylcholine, SM(d18:1/16:0), Sphingomyelin (d18:1/16:0)) |
Catalog No.GC43035
One-Click Copy Product Info
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C16 Sphingomyelin (d18:1/16:0) is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6254-89-3
Sample solution is provided at 25 µL, 10mM.
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C16 Sphingomyelin (d18:1/16:0) is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position [1]. C16 Sphingomyelin interacts favorably with sterols, jointly forming a domain rich in Sphingomyelin/sterols. [2]. The variation in the content of C16 Sphingomyelin can lead to various pathological changes in the placenta[3]. C16 Sphingomyelin (d18:1/16:0) can be used as an internal reference to develop a new type of electrospray ionization mass spectrometry method for identifying related compounds in fibroblast and neuron cells[4].
References:
[1] Chakraborty M, Jiang X C. Sphingomyelin and its role in cellular signaling[J]. Lipid-mediated Protein Signaling, 2013: 1-14.
[2] Slotte J P, Ramstedt B. The functional role of sphingomyelin in cell membranes[J]. European journal of lipid science and technology, 2007, 109(10): 977-981.
[3] Yamazaki K, Masaki N, Kohmura-Kobayashi Y, et al. Decrease in sphingomyelin (d18: 1/16: 0) in stem villi and phosphatidylcholine (16: 0/20: 4) in terminal villi of human term placentas with pathohistological maternal malperfusion[J]. PLoS One, 2015, 10(11): e0142609.
[4] Valsecchi M, Mauri L, Casellato R, et al. Ceramide and sphingomyelin species of fibroblasts and neurons in culture[J]. Journal of lipid research, 2007, 48(2): 417-424.
| Cas No. | 6254-89-3 | SDF | |
| Synonyms | Palmitoyl Sphingomyelin, N-Palmitoyl-D-erythro-Sphingosylphosphorylcholine, SM(d18:1/16:0), Sphingomyelin (d18:1/16:0) | ||
| Canonical SMILES | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O | ||
| Formula | C39H79N2O6P | M.Wt | 703 |
| Solubility | Ethanol: 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.4225 mL | 7.1124 mL | 14.2248 mL |
| 5 mM | 284.5 μL | 1.4225 mL | 2.845 mL |
| 10 mM | 142.2 μL | 711.2 μL | 1.4225 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)