C18 Ganglioside GM2-d3 (d18:1/18:0-d3) (ammonium salt) (Synonyms: C18 GM2-d3, N-omega-CD3-Octadecanoyl monosialoganglioside GM2, Monosialoganglioside GM2-d3, N-Stearoyl Monosialoganglioside GM2-d3)

Name: C18 Ganglioside GM2-d3 (d18:1/18:0-d3) (ammonium salt)
Brand: GlpBio
SKU: GC46993
Availability: InStock
Rating: 5 (9 reviews)

Catalog No.GC46993

A neuropeptide with diverse biological activities

Products are for research use only. Not for human use. We do not sell to patients.

C18 Ganglioside GM2-d3 (d18:1/18:0-d3) (ammonium salt) Chemical Structure

Cas No.: N/A

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250 μg

$839.00

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >99.00%

C18 Ganglioside G_M2-d₃ is intended for use as an internal standard for the quantification of ganglioside G_M2 by GC- or LC-MS. C18 Ganglioside G_M2 is a monosialylated ganglioside found in the mammalian brain where it is localized to the cell membrane.¹ It accumulates in Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively.² Ganglioside G_M2 disrupts the function of immune cells and, when used at a concentration of 25 µM, increases migration and invasion of SK-RC-45 cells with no effect on proliferation.³ [Matreya, LLC. Catalog No. 2051]

1.Schnaar, R.L.Gangliosides of the vertebrate nervous systemJ. Mol. Biol.428(16)3325-3336(2016) 2.Baek, R.C., Martin, D.R., Cox, N.R., et al.Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff diseaseLipids44(3)197-205(2009) 3.Kundu, M., Mahata, B., Banerjee, A., et al.Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathwayBiochim. Biophys. Acta.1863(7 Pt A)1472-1489(2016)

Cas No.	N/A	SDF
Synonyms	C18 GM2-d3, N-omega-CD3-Octadecanoyl monosialoganglioside GM2, Monosialoganglioside GM2-d3, N-Stearoyl Monosialoganglioside GM2-d3
Canonical SMILES	OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@@]2([H])[C@@H]([C@@]([C@H]([C@H](O2)CO)O[C@]3([H])O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)([H])O[C@]4(C([O-])=O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@@H]([C@H](O)CO)O)O4)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O.[NH4+]
Formula	C67H117D3N3O26.NH4	M.Wt	1404.7
Solubility	Chloroform:Methanol:Water (2:1:0.1): Soluble	Storage	Store at -20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	0.7119 mL	3.5595 mL	7.119 mL
	5 mM	0.1424 mL	0.7119 mL	1.4238 mL
	10 mM	0.0712 mL	0.3559 mL	0.7119 mL

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for C18 Ganglioside GM2-d3 (d18:1/18:0-d3) (ammonium salt)

Average Rating: 5 ★★★★★ (Based on Reviews and 9 reference(s) in Google Scholar.)

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C18 Ganglioside GM2-d3 (d18:1/18:0-d3) (ammonium salt) (Synonyms: C18 GM2-d3, N-omega-CD3-Octadecanoyl monosialoganglioside GM2, Monosialoganglioside GM2-d3, N-Stearoyl Monosialoganglioside GM2-d3)

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