Carbamazepine-d10 (Synonyms: Carbazepine-d10, CBZ-d10)

Carbamazepine-d₁₀ is intended for use as an internal standard for the quantification of carbamazepine by GC- or LC-MS. Carbamazepine is an anticonvulsant.^1,2 It reduces the occurrence of seizures in mouse models of tonic-clonic, or maximal electroshock-induced, seizures (ED₅₀s = 15.46 and ~13 mg/kg, respectively). Dietary administration of carbamazepine (0.75% w/w) reduces immobility time in the tail suspension test.³ It also attenuates clonidine-induced aggressive behavior in mice.⁴ Formulations containing carbamazepine have been used in the treatment of epilepsy and bipolar disorder.

1.?uszczki, J.J., Marzeda, P., Gut-Lepiech, A., et al.New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure modelPharmacol. Rep.71(2)299-305(2019) 2.Borowicz-Reutt, K.K., Banach, M., and Rudkowska, M.Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in micePharmacol. Rep.72(1)80-86(2020) 3.Kara, N.Z., Karpel, O., Toker, L., et al.Chronic oral carbamazepine treatment elicits mood-stabilising effects in miceActa Neuropsychiatr.26(1)29-34(2014) 4.Fujiwara, Y., Takeda, T., Kazahaya, Y., et al.Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in miceInt. J. Neurosci.42(1-2)77-84(1988)