GNF351 |
| Catalog No.GC34597 |
GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1227634-69-6
Sample solution is provided at 25 µL, 10mM.
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GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1]. IC50: 62 nM (aryl hydrocarbon receptor)[1]
GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes[1]. Cell Proliferation Assay[1] Cell Line: Human primary keratinocytes
[1]. van den Bogaard EH,et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.
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