APC 366 (trifluoroacetate salt) |
Catalog No.GC42824 |
APC 366 is a mast cell tryptase inhibitor (Ki = 7.1 μM for human recombinant enzyme).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
APC 366 is a mast cell tryptase inhibitor (Ki = 7.1 μM for human recombinant enzyme). It reduces maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs when used at a concentration of 1 μM. Aerosolized APC 366 (5 mg in 1 ml of water) reduces airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. It also reduces collagen content and expression of protease-activated receptor 2 (PAR-2) and α-smooth muscle actin (α-SMA) in rat liver in a model of bile duct ligation-induced liver fibrosis.
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