Chemerin-9 (human) (acetate) (Synonyms: Chemerin (149-157), YFPGQFAFS) |
Catalog No.GC52426 |
A peptide agonist of CMKLR1 and CMKLR2
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chemerin-9 is a peptide agonist of chemokine-like receptor 1 (CMKLR1) and CMKLR2, also known as chemerin receptor 1 (chemerin1) and chemerin2, respectively.1 It is composed of nine C-terminal amino acids of the endogenous human protein chemerin, a chemotactic protein and adipokine involved in the early immune response and energy homeostasis.2 Chemerin-9 binds to CMKLR1 and CMKLR2 (IC50s = 1.9 and 2.3 nM, respectively, in a radioligand binding assay) and induces calcium mobilization in HEK293T cells expressing either CMKLR1 or CMKLR2 and the G protein Gα15 when used at a concentration of 1 µM.3
1.Wittamer, V., GrÉgoire, F., Robberecht, P., et al.The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potencyJ. Biol. Chem.279(11)9956-9962(2004) 2.Fischer, T.F., and Beck-Sickinger, A.G.Chemerin - exploring a versatile adipokineBiol. Chem.403(7)625-642(2022) 3.Barnea, G., Strapps, W., Herrada, G., et al.The genetic design of signaling cascades to record receptor activationProc. Natl. Acad. Sci. USA105(1)64-69(2008)
Cas No. | SDF | Download SDF | |
Synonyms | Chemerin (149-157), YFPGQFAFS | ||
Canonical SMILES | O=C(N(CCC1)[C@@H]1C(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H](CO)C(O)=O)=O)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)=O)=O)=O)[C@@H](NC([C@@H](N)CC(C=C4)=CC=C4O)=O)CC5=CC=CC=C5.CC(O)=O | ||
Formula | C54H66N10O13 ? XC2H4O2 | M.Wt | 1063.2 |
Solubility | DMF: 16 mg/ml,DMSO: 12 mg/ml,Ethanol: Slightly soluble,PBS (pH 7.2): 0.3 mg/ml | Storage | -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.9406 mL | 4.7028 mL | 9.4056 mL |
5 mM | 0.1881 mL | 0.9406 mL | 1.8811 mL |
10 mM | 0.0941 mL | 0.4703 mL | 0.9406 mL |
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
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