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Chemerin-9 (human) (acetate) (Synonyms: Chemerin (149-157), YFPGQFAFS)

Catalog No.GC52426

A peptide agonist of CMKLR1 and CMKLR2

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Chemerin-9 (human) (acetate) Chemical Structure

Size Price Stock Qty
500 μg
$76.00
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1 mg
$144.00
In stock
5 mg
$378.00
In stock
10 mg
$680.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Chemerin-9 is a peptide agonist of chemokine-like receptor 1 (CMKLR1) and CMKLR2, also known as chemerin receptor 1 (chemerin1) and chemerin2, respectively.1 It is composed of nine C-terminal amino acids of the endogenous human protein chemerin, a chemotactic protein and adipokine involved in the early immune response and energy homeostasis.2 Chemerin-9 binds to CMKLR1 and CMKLR2 (IC50s = 1.9 and 2.3 nM, respectively, in a radioligand binding assay) and induces calcium mobilization in HEK293T cells expressing either CMKLR1 or CMKLR2 and the G protein Gα15 when used at a concentration of 1 µM.3

1.Wittamer, V., GrÉgoire, F., Robberecht, P., et al.The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potencyJ. Biol. Chem.279(11)9956-9962(2004) 2.Fischer, T.F., and Beck-Sickinger, A.G.Chemerin - exploring a versatile adipokineBiol. Chem.403(7)625-642(2022) 3.Barnea, G., Strapps, W., Herrada, G., et al.The genetic design of signaling cascades to record receptor activationProc. Natl. Acad. Sci. USA105(1)64-69(2008)

Chemical Properties

Cas No. SDF Download SDF
Synonyms Chemerin (149-157), YFPGQFAFS
Canonical SMILES O=C(N(CCC1)[C@@H]1C(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H](CO)C(O)=O)=O)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)=O)=O)=O)[C@@H](NC([C@@H](N)CC(C=C4)=CC=C4O)=O)CC5=CC=CC=C5.CC(O)=O
Formula C54H66N10O13 ? XC2H4O2 M.Wt 1063.2
Solubility DMF: 16 mg/ml,DMSO: 12 mg/ml,Ethanol: Slightly soluble,PBS (pH 7.2): 0.3 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.9406 mL 4.7028 mL 9.4056 mL
5 mM 0.1881 mL 0.9406 mL 1.8811 mL
10 mM 0.0941 mL 0.4703 mL 0.9406 mL
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