CYM 2503 |
| Catalog No.GC49767 |
A GAL2 receptor positive allosteric modulator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1308833-36-4
Sample solution is provided at 25 µL, 10mM.
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CYM 2503 is a positive allosteric modulator (PAM) of the galanin-2 (GAL2) receptor.1 It enhances the production of inositol monophosphate (IP1) induced by galanin in HEK293 cells expressing the GAL2 receptor (EC50 = 0.69 µM). CYM 2503 (60 mg/kg) increases the latency to first electrographic and behavioral seizures and reduces mortality in a lithium-pilocarpine (Li-pilocarpine) rat model of status epilepticus.
1.Lu, X., Roberts, E., Xia, F., et al.GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal modelsProc. Natl. Acad. Sci. USA107(34)15229-15234(2010)
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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