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Col003

Katalog-Nr.GC34539

Col003 ist ein selektiver und wirksamer Inhibitor vonHsp47 und bindet kompetitiv an die Kollagenbindungsstelle von Hsp47 (IC50 = 1,8μM).

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Col003 Chemische Struktur

Cas No.: 328565-16-8

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5mg
72,00 $
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10mg
122,00 $
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25mg
252,00 $
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50mg
405,00 $
Auf Lager
100mg
630,00 $
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix[1]. HSP47|1.8 μM (IC50)

[1]. Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.

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Average Rating: 5 ★★★★★ (Based on Reviews and 32 reference(s) in Google Scholar.)

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