Defensin HNP-2 (human) (trifluoroacetate salt) (Synonyms: DEFA2 Protein, α-Defensin 2, Human Neutrophil Peptide 2, Neutrophil Defensin 2) |
| Catalog No.GC43397 |
Defensin HNP-2 is a peptide with antimicrobial properties that is secreted by human polymorphonuclear leukocytes (PMNs).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Defensin HNP-2 is a peptide with antimicrobial properties that is secreted by human polymorphonuclear leukocytes (PMNs). It induces 26.2 and 43.5% lysis of mammalian cells at concentrations of 25 and 100 μg/ml, respectively. It also completely inhibits secretion of the exotoxin superantigen TSS toxin-1 (TSST-1) from S. aureus at a concentration of 5 ng/ml and inhibits infection of McCoy cells by C. trachomatis elementary bodies (EBs). Defensin HNP-2 binds to recombinant HIV-1 envelope glycoprotein gp120 and human CD4 (Kds = 8 and 15.8 nM, respectively). It also induces permeabilization of large unilamellar vesicles (LUVs) formed from 1-palmitoyl-2-oleoyl-sn-glycero-3-PG .
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