Ergosterol Peroxide (Synonyms: Ergosterol Endoperoxide, NSC 31324) |
Catalog No.GC47302
One-Click Copy Product Info
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An oxidized sterol with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2061-64-5
Sample solution is provided at 25 µL, 10mM.
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Ergosterol peroxide is an oxidized sterol and derivative of ergosterol that has been found in S. aspratus and has diverse biological activities.1,2,3,4,5 It is active against the P. falciparum chloroquine-sensitive strain FCA 20/GHA with an IC50 value of 8.2 µM.2 Ergosterol peroxide (6.25-50 µM) induces apoptosis in LNCaP and DU145 prostate cancer cells.3 It inhibits growth of SNU-1 gastric, SNU-354 hepatoma, and SNU-C4 colorectal cancer cells (IC50s = 18.7, 158.2, and 84.6 µM, respectively).6 Ergosterol peroxide (60 µM) inhibits LPS-induced NF-kB DNA-binding activity and production of TNF-α in RAW 264.7 cells.4 Topical application of ergosterol peroxide reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate with an ID50 value of 0.2 mg/ear.5
1.Nielson, J.R., Fredrickson, E.K., Waller, T.C., et al.Sterol oxidation mediates stress-responsive Vms1 translocation to mitochondriaMol. Cell68(4)673-685(2017) 2.Kuria, K.A.M., Chepkwony, H., Govaerts, C., et al.The antiplasmodial activity of isolates from Ajuga remotaJ. Nat. Prod.65(5)789-793(2002) 3.Russo, A., Cardile, V., Piovano, M., et al.Pro-apoptotic activity of ergosterol peroxide and (22E)-ergosta-7,22-dien-5α-hydroxy-3,6-dione in human prostate cancer cellsChem. Biol. Interact.184(3)352-358(2010) 4.Kobori, M., Yoshida, M., Ohnishi-Kameyama, M., et al.Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cellsBr. J. Pharmacol.150(2)209-219(2007) 5.Yasukawa, K., Aoki, T., Takido, M., et al.Inhibitory effects of ergosterol isolated from the edible mushroom Hypsizigus marmoreus on TPA‐induced inflammatory ear oedema and tumour promotion in micePhytother. Res.8(1)10-13(1994) 6.Nam, K.S., Jo, Y.S., Kim, Y.H., et al.Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipesLife Sci.69(2)229-237(2001)
| Cas No. | 2061-64-5 | SDF | |
| Synonyms | Ergosterol Endoperoxide, NSC 31324 | ||
| Canonical SMILES | CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@@]3(OO4)C=C[C@@]54C[C@@H](O)CC[C@]5(C)[C@@]3([H])CC[C@@]21C | ||
| Formula | C28H44O3 | M.Wt | 428.7 |
| Solubility | DMSO : 11.11 mg/mL (25.92 mM; Need ultrasonic and warming) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3326 mL | 11.6632 mL | 23.3263 mL |
| 5 mM | 466.5 μL | 2.3326 mL | 4.6653 mL |
| 10 mM | 233.3 μL | 1.1663 mL | 2.3326 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)