Fexofenadine-d10 (hydrochloride) (Synonyms: MDL-16455-d10 hydrochloride; Terfenadine carboxylate-d10 hydrochloride) |
| Catalog No.GC47347 |
An internal standard for the quantification of fexofenadine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1215821-44-5
Sample solution is provided at 25 µL, 10mM.
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Fexofenadine-d10 is intended for use as an internal standard for the quantification of fexofenadine by GC- or LC-MS. Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM).1 It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine .2 Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells.3 Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium .
1.Church, M.K., and Church, D.S.Pharmacology of antihistaminesIndian J. Dermatol.58(3)219-224(2013) 2.Lai, W.S., Lin, Y.Y., Chu, Y.H., et al.Efficacy of fexofenadine in isolated rat tracheasRhinology51(4)376-380(2013) 3.Koh, S.J., Kim, J.W., Kim, B.G., et al.Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in miceJ. Pharmacol. Exp. Ther.352(3)455-461(2015)
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