Fluprostenol-d4 (Synonyms: 16mtrifluoromethylphenoxy tetranor Prostaglandin F2αd4)

Fluprostenol-d₄ contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of fluprostenol by GC- or LC-mass spectrometry. Fluprostenol is a metabolically stable analog of prostaglandin F_2α (PGF_2α) with potent FP receptor agonist activity.1^1,2 It inhibits PGF_2α binding to human and rat FP receptors with IC₅₀ values of 3.5 and 7.5 nM, respectively.^1,2 Fluprostenol is a much more potent luteolytic agent than PGF_2α in rats with a minimum fully effective dose of 270 . g/kg to terminate pregnancy.³ It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC₅₀ value of 3-10 x 10^-11 M.⁴

1.Dukes, M., Russell, W., and Walpole, A.L.Potent luteolytic agents related to prostaglandin F2αNature250(464)330-331(1974) 2.Lake, S., Gullberg, H., Wahlqvist, J., et al.Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptorFEBS Letters355317-325(1994) 3.Abramovitz, M., Boie, Y., Nguyen, T., et al.Cloning and expression of a cDNA for the human prostanoid FP receptorThe Journal of Biological Chemisty2692632-2636(1994) 4.Serrero, G., and Lepak, N.M.Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined mediumBiochemical and Biophysical Research Communications233(1)200-202(1997)