Fluridone (Standard) |
Catalog No.GC49125
One-Click Copy Product Info
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Fluridone is a potent inhibitor of abscisic acid (ABA) biosynthesis and is used as a herbicide, particularly for the elimination of aquatic plants in reservoirs and irrigation channels.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 59756-60-4
Sample solution is provided at 25 µL, 10mM.
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Fluridone is a potent inhibitor of abscisic acid (ABA) biosynthesis and is used as a herbicide, particularly for the elimination of aquatic plants in reservoirs and irrigation channels[1].
Treatment of kiwifruit wound tissue with Fluridone inhibited the levels of transcription factors AchnMYB41, AchnMYB107 and AchnMYC2 and reduced primary alcohol formation[1]. Fluridone (50 and 100μM) induced the accumulation of phytoene and reduced β-carotene levels in T. aestivum seedlings grown in the dark[2].
Fluridone reduces the hatching success rate of medaka embryos in a dose-dependent manner, with the maximum effective concentration for hatching success being 2.3mg/L. Male and female medaka larvae were acutely exposed to Fluridone for 6 hours. Fluridone at concentrations of 4.2mg/L or higher caused the larvae to become lethargic and exhibit abnormal swimming behavior[3]. Fluridone is acutely toxic to invertebrates and fish, with median lethal concentrations (LC50) of 4.3 ± 3.7 and 10.4 ± 3.9mg/L, respectively[4].
References:
[1] Wei X, Mao L, Wei X, Xia M, Xu C. MYB41, MYB107, and MYC2 promote ABA-mediated primary fatty alcohol accumulation via activation of AchnFAR in wound suberization in kiwifruit. Hortic Res. 2020 Jun 1;7(1):86.
[2] Bartels P G, Watson C W. Inhibition of carotenoid synthesis by fluridone and norflurazon[J]. Weed Science, 1978, 26(2): 198-203.
[3] Jin J, Kurobe T, Hammock B G, et al. Toxic effects of fluridone on early developmental stages of Japanese Medaka (Oryzias latipes)[J]. Science of the Total Environment, 2020, 700: 134495.
[4] Hamelink J L, Buckler D R, Mayer F L, et al. Toxicity of fluridone to aquatic invertebrates and fish[J]. Environmental Toxicology and Chemistry: An International Journal, 1986, 5(1): 87-94.
| Cell experiment [1]: | |
Cell lines | S. capricornutum cells |
Preparation Method | The concentrations of total colored carotenoid pigments were determined for each Fluridone treatment by a standard spectrophotometric method. |
Reaction Conditions | 1.65, 3.3 and 33μg/L, 48h |
Applications | Concentrations of colored carotenoid pigments in S. capricornutum cells were reduced after 48h exposure, relative to the no Fluridone treatments, to concentrations of Fluridone greater than 3.3μg/L. |
| Animal experiment [2]: | |
Animal models | Male and female Medaka embryos ( < 6h post fertilization） |
Preparation Method | Then 50 healthy embryos were placed in each 50mL Pyrex beakers containing 15mL of Fluridone solution for batch exposure (one beaker per concentration). A 50% (7.5mL) solution was changed at 2 d post exposure (dpe). At 4 dpe, embryos were separated by sex based on the presence of leucophores on males and then transferred into 96-well plates. Each well had one embryo placed inside and contained 200mL of experimental solution. A total of 16 embryos for each sex were used per treatment. More than 80% of the volume in each well was changed every 2 days for the remainder of the experiment. Each embryo was observed daily using a dissecting microscope and recorded for mortality, hatching success, and signs of abnormal development. The experiment was terminated at 14 dpe (4 days in beaker, 10 days in plate), and fish embryos that failed to hatch were counted. |
Dosage form | 0, 0.03, 0.5, 1, 2 and 4mg/L, 14 days |
Applications | Male and female Medaka embryos were exposed to Fluridone for 14 days and showed reduced hatching success in a dose dependent manner. The half maximal effective concentration for the hatching success was 2.3mg/L. |
References: [1] Gala W R, Giesy J P. Using the carotenoid biosynthesis inhibiting herbicide, Fluridone, to investigate the ability of carotenoid pigments to protect algae from the photo-induced toxicity of anthracene[J]. Aquatic toxicology, 1993, 27(1-2): 61-70. [2] Jin J, Kurobe T, Hammock B G, et al. Toxic effects of fluridone on early developmental stages of Japanese Medaka (Oryzias latipes)[J]. Science of the Total Environment, 2020, 700: 134495. | |
| Cas No. | 59756-60-4 | SDF | |
| Canonical SMILES | O=C1C(C2=CC=CC=C2)=CN(C)C=C1C3=CC(C(F)(F)F)=CC=C3 | ||
| Formula | C19H14F3NO | M.Wt | 329.3 |
| Solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 20 mg/ml | Storage | Store at -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0367 mL | 15.1837 mL | 30.3674 mL |
| 5 mM | 607.3 μL | 3.0367 mL | 6.0735 mL |
| 10 mM | 303.7 μL | 1.5184 mL | 3.0367 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)