Fotemustine (S10036) |
| Catalog No.GC32827 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 92118-27-9
Sample solution is provided at 25 µL, 10mM.
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Fotemustine is a DNA-alkylating agent, with antitumor activity.
Fotemustine is a DNA-alkylating agent. Fotemustine (800 μM) decreases GSH and intracellular GSSG levels but increases the extracellular GSSG-levels rapidly in isolated rat hepatocytes[1]. Fotemustine shows inhibitory effect on several tumor cell lines, with IC50s ranging form 0.05 to 0.18 mM[2].
[1]. Brakenhoff JP, et al. Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions. Carcinogenesis. 1996 Apr;17(4):715-24. [2]. Merlin JL, et al. Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. Anticancer Drugs. 2002 Feb;13(2):141-7.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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