Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh, 0.3-0.6 mmol/g) |
Catalog No.GA21562 |
This resin has been developed to allow C-terminal modification of cysteine-containing peptides. Fmoc-protected cysteine is linked to SASRIN™-resin by its thiol moiety, which thus is already protected. After derivatization of the carboxylic acid (and, if desired, standard Fmoc-SPPS) lthe modified cysteine derivative can be cleaved with TFA/water/triisopropylsilane (94:4:2, v/v/v) from the SASRIN™-resin. Extending the peptide chain at the C-terminus can be achieved by activation of the side-chain linked cysteine carboxylic acid and coupling to additional amino acids. Cys linked to a resin by its thiol function was oxidized with MCPBA after esterification and Nα-modification (Yamada et al.). DBU-induced elimination yielded dehydroalanine derivatives.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
This resin has been developed to allow C-terminal modification of cysteine-containing peptides. Fmoc-protected cysteine is linked to SASRIN™-resin by its thiol moiety, which thus is already protected. After derivatization of the carboxylic acid (
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