H-Phe-Tyr-OH |
Catalog No.GA22818
One-Click Copy Product Info
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H-Phe-Tyr-OH is a dipeptide composed of two amino acids, L-phenylalanine (Phe) and L-tyrosine (Tyr), with a free amino group at the N-terminus and a free carboxyl group at the C-terminus.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 17355-18-9
Sample solution is provided at 25 µL, 10mM.
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H-Phe-Tyr-OH is a dipeptide composed of two amino acids, L-phenylalanine (Phe) and L-tyrosine (Tyr), with a free amino group at the N-terminus and a free carboxyl group at the C-terminus. H-Phe-Tyr-OH dipeptide can inhibit Angiotensin-Converting Enzyme (ACE) activity and is often used as a drug to treat hypertension, cardiovascular disease and diabetic nephropathy[1]. In spontaneously hypertensive rats, a single oral administration of H-Phe-Tyr-OH at 1mg/kg reduced systolic blood pressure by 16mmHg, while a dose of 10mg/kg reduced systolic blood pressure by 21mmHg[2].
References:
[1] Kecel-Gündüz S, Budama-Kilinc Y, Cakir Koc R, et al. Computational design of Phe-Tyr dipeptide and preparation, characterization, cytotoxicity studies of Phe-Tyr dipeptide loaded PLGA nanoparticles for the treatment of hypertension. J Biomol Struct Dyn. 2018;36(11):2893-2907.
[2] Sato M, Hosokawa T, Yamaguchi T, et al. Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. J Agric Food Chem. 2002;50(21):6245-6252.
| Animal experiment [1]: | |
Animal models | Spontaneously Hypertensive Rat（SHR） |
Preparation Method | Single oral administration test in SHR was performed at the dose level of 1 or 10mg/kg H-Phe-Tyr-OH. Detect blood pressure after drug administration |
Dosage form | 1 or 10mg/kg; p.o. |
Applications | Significant reductions of -21mmHg at 10mg/kg, -16mmHg at 1mg/kg were observed. |
References: | |
| Cas No. | 17355-18-9 | SDF | |
| Formula | C18H20N2O4 | M.Wt | 328.37 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0453 mL | 15.2267 mL | 30.4535 mL |
| 5 mM | 609.1 μL | 3.0453 mL | 6.0907 mL |
| 10 mM | 304.5 μL | 1.5227 mL | 3.0453 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)