OM99-2 |
Catalog No.GA23320
One-Click Copy Product Info
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OM99-2, an eight-residue peptidomimetic, is a potent inhibitor of brain Memapsin 2 with a Ki value of 9.58nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 314266-76-7
Sample solution is provided at 25 µL, 10mM.
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OM99-2, an eight-residue peptidomimetic, is a potent inhibitor of brain Memapsin 2 with a Ki value of 9.58nM [1]. OM99-2 has been used as a lead compound for rational drug design, through site modification to construct BACE-1 inhibitors and to screen for potent multi-target neuroprotective agents [2]. OM99-2 was used as a model compound to determine the protonation state of the active site of β-secretase through molecular dynamics simulations and molecular docking experiments [3].
References:
[1] Ghosh A K, Shin D, Downs D, et al. Design of potent inhibitors for human brain memapsin 2 (β-secretase)[J]. Journal of the American Chemical Society, 2000, 122(14): 3522-3523.
[2] Zhang W T, Jiang F C, Liu D, et al. Pharmacopore hypothesis generation of BACE-1 inhibitors and pharmacophore-driven identification of potent multi-target neuroprotective agents[J]. Medicinal Chemistry Research, 2012, 21(11): 3656-3668.
[3] Park H, Lee S. Determination of the active site protonation state of β-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design[J]. Journal of the American Chemical Society, 2003, 125(52): 16416-16422.
| Cas No. | 314266-76-7 | SDF | |
| Formula | C41H64N8O14 | M.Wt | 893.01 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1198 mL | 5.599 mL | 11.1981 mL |
| 5 mM | 224 μL | 1.1198 mL | 2.2396 mL |
| 10 mM | 112 μL | 559.9 μL | 1.1198 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)