LB244 |
Catalog No.GC27999
One-Click Copy Product Info
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LB244 is a homologue of BB-Cl-amidine, which is an orally effective STING inhibitor (EC50=0.8 μM) and can be used to inhibit STING-dependent inflammatory diseases.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3074622-05-9
Sample solution is provided at 25 µL, 10mM.
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LB244 is a homologue of BB-Cl-amidine, which is an orally effective STING inhibitor (EC50=0.8 μM) and can be used to inhibit STING-dependent inflammatory diseases. The pharmacokinetic properties of LB244 indicate limited oral activity in mice[1].
Pharmacokinetic results for LB244 (10 mg/kg, p.o.; 5 mg/kg, i.p.) in mice indicate limited oral activity (Cmax = 0.04 μM) and a short half-life (T1/2 = 2.8 h). Its in vivo clearance rate is 2854.3 mL/min/kg[1].
References:
[1]. Barasa L, et al. Development of LB244, an Irreversible STING Antagonist. J Am Chem Soc. 2023 Sep 20;145(37):20273-20288..
| Cas No. | 3074622-05-9 | SDF | |
| Chemical Name | 2-Furancarboxamide, N-[(5S)-5-(1H-benzimidazol-2-yl)-5-[([1,1′-biphenyl]-4-ylcarbonyl)amino]p entyl]-5-nitro- | ||
| Formula | C30H27N5O5 | M.Wt | 537.57 |
| Solubility | DMSO : 100 mg/mL (186.02 mM; Need ultrasonic) | Storage | -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.8602 mL | 9.3011 mL | 18.6022 mL |
| 5 mM | 372 μL | 1.8602 mL | 3.7204 mL |
| 10 mM | 186 μL | 930.1 μL | 1.8602 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)