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Mavorixafor trihydrochloride (Synonyms: AMD-070 trihydrochloride)

Catalog No.GC36550

Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively.

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Mavorixafor trihydrochloride Chemical Structure

Cas No.: 2309699-17-8

Size Price Stock Qty
10mM (in 1mL DMSO)
$131.00
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2mg
$83.00
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5mg
$130.00
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10mg
$232.00
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50mg
$788.00
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100mg
$1,298.00
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Sample solution is provided at 25 µL, 10mM.

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Background

Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. 125I-SDF-CXCR4|13 nM (IC50)|HIV-1 (NL4.3 strain)|1 nM (IC50, in MT-4 cells)|HIV-1 (NL4.3 strain)|9 nM (IC50, in PBMCs)|HIV-1 (NL4.3 strain)|3 nM (IC90, in MT-4 cells)|HIV-1 (NL4.3 strain)|26 nM (IC90, in PBMCs)

Mavorixafor (AMD-070) is a potent and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. Mavorixafor (AMD-070) shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2)[1]. Mavorixafor (AMD-070) (6.6 µM) significantly suppresses the anchorage-dependent growth, the migration and matrigel invasion of the B88-SDF-1 cells[2].

Mavorixafor (AMD-070) (2 mg/kg, p.o.) significantly reduces the number of metastatic lung nodules in mice, and lowers the expression of human Alu DNA in mice, without body weight loss[2].

[1]. Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88. [2]. Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. Oncol Rep. 2018 Jul;40(1):303-308.

Chemical Properties

Cas No. 2309699-17-8 SDF
Synonyms AMD-070 trihydrochloride
Canonical SMILES [H]Cl.[H]Cl.[H]Cl.NCCCCN(CC1=NC2=CC=CC=C2N1)[C@@H]3C4=NC=CC=C4CCC3
Formula C21H30Cl3N5 M.Wt 458.86
Solubility DMSO: 6 mg/mL (13.08 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.1793 mL 10.8966 mL 21.7931 mL
5 mM 0.4359 mL 2.1793 mL 4.3586 mL
10 mM 0.2179 mL 1.0897 mL 2.1793 mL
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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 36 reference(s) in Google Scholar.)

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