4-oxo-27-TBDMS Withaferin A |
| Catalog No.GC45353 |
4-oxo-27-TBDMS Withaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.4-oxo-27-TBDMS Withaferin A induces tumor cells apoptosis. 4-oxo-27-TBDMS Withaferin A is a anticancer agent.
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Cas No.: 1214886-31-3
Sample solution is provided at 25 µL, 10mM.
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4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.
References
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).
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