1-Methylcyclopropene (Synonyms: 1-MCP) |
Catalog No.GD17933
One-Click Copy Product Info
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1-Methylcyclopropene, a gas with a molecular weight of 54.09g/mol is an inhibitor of ethylene action.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3100-04-7
Sample solution is provided at 25 µL, 10mM.
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1-Methylcyclopropene, a gas with a molecular weight of 54.09g/mol is an inhibitor of ethylene action[1]. By competitively binding to ethylene receptors, 1-Methylcyclopropene effectively inhibits the ethylene signaling pathway, thereby delaying plant maturation, senescence, and stress-induced physiological disorders[2]. 1-Methylcyclopropene is capable of regulating the reactive oxygen species (ROS) scavenging system via activation of the mitogen-activated protein kinase (MAPK) signaling pathway, thereby establishing an ethylene-independent antioxidant defense mechanism[3]. 1-Methylcyclopropene has been widely used in the research on fruit preservation to reduce ethylene production and respiration, and inhibited fruit softening and titratable acidity loss[4-5].
In vitro, 1-Methylcyclopropene (1µL/L) of pretreatment for 24 hours can delay the softening of Actinidia arguta fruit within 49 days by reducing the activity of cell wall modifying enzymes[6].
In vivo, 1-Methylcyclopropene treatment via oral administration of at a dose of 6.5mg/kg/day for 8 weeks induced liver injury and dysfunction, as well as oxidative stress and lipid peroxidation in Wistar rats[7].
References:
[1] Blankenship S M, Dole J M. 1-Methylcyclopropene: a review[J]. Postharvest biology and technology, 2003, 28(1): 1-25.
[2] Guo S M, Xue K Y, Si S Y, et al. Mechanisms of 1-methylcyclopropene (1-MCP) in regulating ethylene signal transduction and its role in stress responses: a review[J]. Plant Science, 2025: 112918.
[3] Guo F, Han J, Jin M, et al. Effects of sucrose and 1-MCP on enzymatic and nonenzymatic antioxidants in postharvest Gynura bicolor DC[J]. Plant Physiology and Biochemistry, 2025, 219: 109319.
[4] Watkins C B. The use of 1-methylcyclopropene (1-MCP) on fruits and vegetables[J]. Biotechnology advances, 2006, 24(4): 389-409.
[5] DeEll J R, Murr D P, Porteous M D, et al. Influence of temperature and duration of 1-methylcyclopropene (1-MCP) treatment on apple quality[J]. Postharvest biology and Technology, 2002, 24(3): 349-353.
[6] Xiong S, Sun X, Tian M, et al. 1-Methylcyclopropene treatment delays the softening of Actinidia arguta fruit by reducing cell wall degradation and modulating carbohydrate metabolism[J]. Food Chemistry, 2023, 411: 135485.
[7] Ouali A, Boukerche S, Trea F, et al. In vivo and in silico studies assessment of the effects of oral exposure to 1-methylcyclopropene on liver function in male albino rats[J]. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 2024, 94(3): 597-606.
| Animal experiment [1]: | |
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Animal models |
Male Wistar rats |
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Preparation Method |
Male Wistar rats were housed individually in specific cages and placed in a ventilated cabinet, temperature was kept relatively constant at 22°C (± 3°C) and humidity between 50 and 70%, and the lighting was controlled to be 12h light and 12h dark. Rats received clean tap water and a standard diet ad libitum during all the length of the experiment. An appropriate amount of 1-Methylcyclopropene powder was diluted in sunflower oil to make the 6.5mg/kg dose of 1-Methylcyclopropene, which was then administered to the rats orally with a gastric tube. The treatment was carried out daily for 8 consecutive weeks. The control group received only sunflower oil. At the end of the experiment, the rats were sacrificed by decapitation; the liver was then collected for analysis. |
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Dosage form |
6.5mg/kg/day; 8 weeks; p.o. |
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Applications |
1-Methylcyclopropene treatment caused liver damage and dysfunction in rats, along with abnormal architecture, necrosis, and infiltration of lymphocytes. |
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References: [1] Ouali A, Boukerche S, Trea F, et al. In vivo and in silico studies assessment of the effects of oral exposure to 1-methylcyclopropene on liver function in male albino rats[J]. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 2024, 94(3): 597-606. |
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| Cas No. | 3100-04-7 | SDF | |
| Synonyms | 1-MCP | ||
| Formula | C4H6 | M.Wt | 54.09 |
| Solubility | Storage | 2-8°C ,protect from light | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 18.4877 mL | 92.4385 mL | 184.8771 mL |
| 5 mM | 3.6975 mL | 18.4877 mL | 36.9754 mL |
| 10 mM | 1.8488 mL | 9.2439 mL | 18.4877 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)