Nafion117 solution |
Catalog No.GD18838
One-Click Copy Product Info
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Nafion117 solution is a solution of a copolymer of perfluorosulfonic acid and polytetrafluoroethylene, characterized by its selective transport of cations.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 31175-20-9
Sample solution is provided at 25 µL, 10mM.
Nafion117 solution is a solution of a copolymer of perfluorosulfonic acid and polytetrafluoroethylene, characterized by its selective transport of cations[1] . Nafion117 solution can be used to form ionomer membranes with good water absorption and ionic conductivity，and is commonly used in proton exchange membrane fuel cells, electrodialysis, and electrochemical sensors[2-4]. Additionally, due to its good biocompatibility, Nafion117 solution can also be used for the preparation of biosensors, drug delivery systems, and antibacterial coatings[5-7].
References:
[1] Lufrano, E., Simari, C., Di Vona, M. L., Nicotera, I., & Narducci, R. (2021). How the Morphology of Nafion-Based Membranes Affects Proton Transport. Polymers, 13(3), 359.
[2] Naik, A. N., Agarwal, C., Chaudhury, S., & Goswami, A. (2017). Effect of Film Diffusion on the Ion-Exchange Kinetics of a Tracer Ion in Nafion-117 Membrane from a Mixture of Salt Solution. The journal of physical chemistry. B, 121(43), 10081–10090.
[3] Avci, A. H., Messana, D. A., Santoro, S., Tufa, R. A., Curcio, E., Di Profio, G., & Fontananova, E. (2020). Energy Harvesting from Brines by Reverse Electrodialysis Using Nafion Membranes. Membranes, 10(8), 168.
[4] Polino, M., Rho, H. S., Pina, M. P., Mallada, R., Carvalho, A. L., Romão, M. J., Coelhoso, I., Gardeniers, J. G. E., Crespo, J. G., & Portugal, C. A. M. (2021). Protein Crystallization in a Microfluidic Contactor with Nafion®117 Membranes. Membranes, 11(8), 549.
[5] Dai, Z., & Möhwald, H. (2002). Highly stable and biocompatible nafion-based capsules with controlled permeability for low-molecular-weight species. Chemistry (Weinheim an der Bergstrasse, Germany), 8(20), 4751–4755.
[6] Yoshida, K., Sato, K., Ono, T., Dairaku, T., & Kashiwagi, Y. (2018). Preparation of Nafion/Polycation Layer-by-Layer Films for Adsorption and Release of Insulin. Polymers, 10(8), 812.
[7] Gibbons, E. N., Winder, C., Barron, E., Fernandes, D., Krysmann, M. J., Kelarakis, A., Parry, A. V. S., & Yeates, S. G. (2019). Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan. Nanomaterials (Basel, Switzerland), 9(11), 1563.
Protocol for Nafion117 soluion -Based Layer-by-Layer Film Preparation for Drug Delivery:
1. Clean the Au surface layer of the quartz resonator with piranha solution (a mixture of H2O2 and H2SO4, 1:3 v/v).
2. Rinse thoroughly in pure water.
3. Immerse the cleaned quartz resonator in an aqueous solution of cystamine dihydrochloride (5mM) for 12h to make a positively charged surface on the Au surface layer.
4. Rinse the surface with pure water.
5. Expose the surface to a solution of 0.5mg/mL Nafion117 solution(NAF) in 10mM Tris buffer containing 150mM NaCl (pH 7.4) for 15min to deposit the first NAF layer.
6. Rinse with the working buffer(10mM Tris buffer in 150mM NaCl (pH 7.4) ) for 5min.
7. Expose the NAF-deposited quartz resonator to 0.5mg/mL polycation solution in the Tris buffer (pH7.4) for 15min.
8. Rinse with the Tris buffer for 5min.
9. Repeat the deposition steps for NAF and polycation to prepare the LbL films consisting of NAF and PAH, PEI, and PDDA.
10. Rinse the film-deposited probe in milli-Q water for 1min and the deposition process of the film was monitored using a Quartz Crystal Microbalance (QCM).
11. Dry the film-deposited probe in air until the frequency showed a steady-state value.
12. The LbL films can be used for drug adsorption.
This protocol only provides a guideline, and should be modified according to your specific needs.
Reference:
[1] Yoshida, K., Sato, K., Ono, T., Dairaku, T., & Kashiwagi, Y. (2018). Preparation of Nafion/Polycation Layer-by-Layer Films for Adsorption and Release of Insulin. Polymers, 10(8), 812.
| Cas No. | 31175-20-9 | SDF | |
| Formula | M.Wt | ||
| Solubility | Storage | Store at room temperature | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)