Neophytadiene |
Catalog No.GD19131
One-Click Copy Product Info
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 504-96-1
Sample solution is provided at 25 µL, 10mM.
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Neophytadiene has cytotoxic on RAW 264.7 cells with an IC50 of 50 渭M[1].
Neophytadiene (50-100 渭M; 30 min) successfully inhibits the NO production level and downregulates inducible nitric oxide synthase (iNOS) production in LPS (1 渭g/mL)-induced RAW264.7 cells[1].
Neophytadiene (25-100 渭M; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-伪, IL-6 and IL-10 and IL-10 in LPS (1 渭g/mL)-induced RAW264.7 cells[1].
Neophytadiene (50 mg/kg; p.o.; daily; for 7 days) shows dose-dependent reduction in the alanine aminotransferase (ALT) level[1].
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased IL-6 and 1L-10 levels and in heart tissue[1].
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased PGE2 mRNA expression in heart tissue[1].
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-伪, IL-6 and IL-10 and IL-10 in vivo[1].
[1]. Meenakshi Bhardwaj, et al. Neophytadiene from Turbinaria ornata Suppresses LPS-Induced Inflammatory Response in RAW 264.7 Macrophages and Sprague Dawley Rats. Inflammation. 2020 Jun;43(3):937-950.
| Cas No. | 504-96-1 | SDF | |
| Formula | C20H38 | M.Wt | 278.52 |
| Solubility | Storage | -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.5904 mL | 17.952 mL | 35.9041 mL |
| 5 mM | 718.1 μL | 3.5904 mL | 7.1808 mL |
| 10 mM | 359 μL | 1.7952 mL | 3.5904 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)