Polyglycolide |
Catalog No.GD20509
One-Click Copy Product Info
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Polyglycolide is a thermoplastic and highly crystalline biodegradable polymer derived from glycolic acid.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 26124-68-5
Sample solution is provided at 25 µL, 10mM.
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Polyglycolide is a thermoplastic and highly crystalline biodegradable polymer derived from glycolic acid[1,2]. Polyglycolide exhibits high mechanical strength, good biocompatibility, and tunable degradation rates, making it commonly used in bioabsorbable surgical sutures and tissue repair materials[3,4,5].
In vitro, Balb/3T3 clone A31 mouse embryonic fibroblasts were seeded onto Polyglycolide films at a density of 3×104 cells/well for 1h, resulting in a cell adhesion rate of 60.25 ± 2.96%. When seeded at a density of 1×104 cells/well for 72h, the cell proliferation rate on the Polyglycolide films was 8.69 ± 8.27%[6].
In vivo, Polyglycolide scaffolds seeded with tooth germ bud from 4-day-old rats (static seeding for 1h) were implanted into the greater omentum of adult Lewis rats for 12 weeks, and highly mineralized tooth tissue formed in 88% of the Polyglycolide scaffold implants[7].
References:
[1] SAMANTARAY P K, LITTLE A, HADDLETON D M, et al. Poly (glycolic acid)(PGA): a versatile building block expanding high performance and sustainable bioplastic applications[J]. Green Chemistry, 2020, 22(13): 4055-4081.
[2] CIPURKOVIĆ A, HOROZIĆ E, ĐONLAGIĆ N, et al. Biodegradable polymers: production, properties and application in medicine[J]. Technologica Acta: Scientific/professional journal of chemistry and technology, 2018, 11(1): 25-35.
[3] ASHAMMAKHI N, ROKKANEN P. Absorbable polyglycolide devices in trauma and bone surgery[J]. Biomaterials, 1997, 18(1): 3-9.
[4] DOPPALAPUDI S, JAIN A, KHAN W, et al. Biodegradable polymers—an overview[J]. Polymers for Advanced Technologies, 2014, 25(5): 427-435.
[5] TÖRMÄLÄ P, POHJONEN T, ROKKANEN P. Bioabsorbable polymers: materials technology and surgical applications[J]. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 1998, 212(2): 101-111.
[6] BRACCINI S, PECORINI G, CHIELLINI F, et al. Adhesion of fibroblast cells on thin films representing surfaces of polymeric scaffolds of human urethra rationalized by molecular models of integrin binding: cell adhesion on polymeric scaffolds for regenerative medicine[J]. Journal of biotechnology, 2020, 324: 233-238.
[7] DUAILIBI M T, DUAILIBI S E, YOUNG C S, et al. Bioengineered teeth from cultured rat tooth bud cells[J]. Journal of dental research, 2004, 83(7): 523-528.
| Cell experiment [1]: | |
Cell lines | Balb/3T3 clone A31 mouse embryo fibroblasts cells |
Preparation Method | Balb/3T3 clone A31 mouse embryo fibroblasts cells were incubated with 3×104 cells/well for 1h to allow cells to adhesion to the surfaces of Polyglycolide films. The medium was then replaced to remove non-adherent cells, samples were re-placed in new wells with fresh growth medium and cell adhesion was quantified by WST-8 tetrazolium salt reagent. Cells were incubated for 4h with WST-8 reagent diluted 1:10, at 37℃ and 5% CO2. Supernatants were then aliquoted in 96-well culture plates, and formazan dye absorbance measurements were carried out with a microplate reader at 450nm. |
Reaction Conditions | 1h |
Applications | Polyglycolide films can promote cell adhesion, the cell adhesion rate of Balb/3T3 clone A31 mouse embryo fibroblasts cells on the membrane was 60.25 ± 2.96%. |
| Animal experiment [2]: | |
Animal models | Lewis rats |
Preparation Method | Tooth bud cells were isolated from 4-day-old rats and statically seeded onto Polyglycolide scaffolds at a density of approximately 1.5×105 cells per scaffold for 1h. The cell-seeded scaffolds were then surgically implanted into the omenta of Lewis rats. Following 12 weeks of in vivo growth, the implants were harvested and evaluated for the formation of mineralized tooth tissues using radiographic and histological analyses. |
Dosage form | 12 weeks |
Applications | Polyglycolide scaffolds reliably promote the formation of tooth tissue from tooth bud cells. |
References: | |
| Cas No. | 26124-68-5 | SDF | |
| Formula | M.Wt | ||
| Solubility | Storage | RT,protect from light,away from moisture. | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)