Hexaaminobenzene trihydrochloride |
Catalog No.GF10968
One-Click Copy Product Info
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Hexaaminobenzene trihydrochloride is a highly substituted aromatic polyamine hydrochloride with all six positions of the benzene ring fully substituted by amino groups, featuring abundant hydrogen bond donor/acceptor capacity and multisite coordination potential.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4444-26-2
Sample solution is provided at 25 µL, 10mM.
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Hexaaminobenzene trihydrochloride is a highly substituted aromatic polyamine hydrochloride with all six positions of the benzene ring fully substituted by amino groups, featuring abundant hydrogen bond donor/acceptor capacity and multisite coordination potential. Hexaaminobenzene trihydrochloride can be used in research related to coordination chemistry, catalytic materials, organic synthesis intermediates, and construction of adenosine receptor-targeted small molecules[1-4].
References:
[1] Zeng X, Tu Z, Yuan Y, et al. Two-Dimensional Transition Metal-Hexaaminobenzene Monolayer Single-Atom Catalyst for Electrocatalytic Carbon Dioxide Reduction. Nanomaterials (Basel). 2022 Nov 14;12(22):4005.
[2] Park J, Lee M, Feng D, et al. Stabilization of Hexaaminobenzene in a 2D Conductive Metal-Organic Framework for High Power Sodium Storage. J Am Chem Soc. 2018 Aug 15;140(32):10315-10323.
[3] Wolff JJ, Zietsch A, Nuber B, et al. Hexaaminobenzene derivatives: synthesis and unusual oxidation behavior. J Org Chem. 2001 Apr 20;66(8):2769-77.
[4] Huang B, Chen B, Zhu G, et al. Electrochemical Ammonia Synthesis via NO Reduction on 2D-MOF. Chemphyschem. 2022 Feb 16;23(4):e202100785.
Synthesis of Hexaaminobenzene Trihydrochloride-Based 2D Coordination Polymers[1]
This protocol is adapted from research data and provided for reference only. Adjustments may be necessary based on specific experimental requirements.
1. Reagent preparation: Dissolve hexaaminobenzene trihydrochloride in degassed deionized water to prepare the aqueous phase ligand solution. Dissolve M(acac)₂ (M=Ni²⁺, Cu²⁺, Co²⁺; acac=acetylacetonate) in ethyl acetate (EtOAc) as the organic phase.
2. Preparation of thin-layer 2D coordination polymers (CPs): Place the aqueous solution of deprotonated/free-base hexaaminobenzene (derived from the trihydrochloride salt precursor) at the bottom of the reaction vessel. Gently overlay the aqueous surface with the EtOAc solution of M(acac)₂, covering approximately half of the total water-air interfacial area. Allow the reaction to stand for 4h: as EtOAc slowly evaporates, hexaaminobenzene coordinates with M²⁺ at the air-liquid interface via spontaneous condensation to form (hexaiminobenzosemiquinonato)-κₙ-metalthin films (1-M, M = Ni/Cu/Co). Lower a substrate (SiO₂/Si or PDMS) face-down onto the liquid surface, then lift it slowly to transfer the film onto the substrate. Wash the substrate sequentially with deionized water and isopropanol. Subject the substrate bearing the CPs to 10s of ultrasonication in ethyl acetate, followed by baking under dynamic vacuum at 100°C for 12h.
Precautions:
(1) Hexaaminobenzene trihydrochloride is extremely prone to oxidation. The ligand solution must be prepared with degassed deionized water, and air exposure should be minimized throughout the entire process.
(2) For your safety and health, please wear a lab coat and disposable gloves during operation.
References:
[1] Lahiri N, Lotfizadeh N, Tsuchikawa R, et al. Hexaaminobenzene as a building block for a Family of 2D Coordination Polymers. J Am Chem Soc. 2017 Jan 11;139(1):19-22.
| Cas No. | 4444-26-2 | SDF | |
| Formula | C6H12N6 | M.Wt | 277.58 |
| Solubility | Storage | Store at RT | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6026 mL | 18.0128 mL | 36.0257 mL |
| 5 mM | 720.5 μL | 3.6026 mL | 7.2051 mL |
| 10 mM | 360.3 μL | 1.8013 mL | 3.6026 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)