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Dauricumine (Synonyms: Dauricumine)

Catalog No.GF14794 Copy One-Click Copy Product Info

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Dauricumine Chemical Structure

Cas No.: 345641-00-1

Size Price Stock Qty
5mg
$627.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of Dauricumine

Dauricumine is a chlorinated alkaloid that inhibits NF-魏B ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts.

[1]. Sugimoto Y, et, al. Chlorinated alkaloids in Menispermum dauricum DC: root culture. J Org Chem. 2001 May 18;66(10):3299-302. 

[2]. Lee JY, et, al. Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum. Arch Pharm Res. 2016 May;39(5):713-20.  

Chemical Properties of Dauricumine

Cas No. 345641-00-1 SDF
Synonyms Dauricumine
Formula C19H24ClNO6 M.Wt 397.85
Solubility Storage 2-8°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Dauricumine

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5135 mL 12.5676 mL 25.1351 mL
5 mM 502.7 μL 2.5135 mL 5.027 mL
10 mM 251.4 μL 1.2568 mL 2.5135 mL
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In vivo Formulation Calculator (Clear solution) of Dauricumine

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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