GTP binding protein 1 fragment [Multiple species] (Synonyms: H2N-Lys-Val-Ile-Thr-Phe-Ile-Asp-Leu-OH ) |
| Catalog No.GP10004 |
Signal transducing molecules
Products are for research use only. Not for human use. We do not sell to patients.
![GTP binding protein 1 fragment [Multiple species] Chemical Structure](/media/struct/GP1/GP10004.png "GTP binding protein 1 fragment [Multiple species] Chemical Structure")
Sample solution is provided at 25 µL, 10mM.
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GTP binding protein 1 fragment [Multiple species], (C46H77N9O12), a peptide with the sequence H2N-Lys-Val-Ile-Thr-Phe-Ile-Asp-Leu-OH, MW= 948.16. G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins involved in transmitting chemical signals originating from outside a cell into the inside of the cell. G proteins function as molecular switches. Their activity is regulated by factors that control their ability to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they bind GTP, they are 'on', and, when they bind GDP, they are 'off'. G proteins belong to the larger group of enzymes called GTPases(1). G proteins are important signal transducing molecules in cells. "Malfunction of GPCR [G Protein-Coupled Receptor] signaling pathways are involved in many diseases, such as diabetes, blindness, allergies, depression, cardiovascular defects, and certain forms of cancer. It is estimated that more than half of the modern drugs' cellular targets are GPCRs." (2)The human genome encodes roughly 950 G protein-coupled receptors, which detect photons (light), hormones, growth factors, drugs, and other endogenous ligands. Approximately 150 of the GPCRs found in the human genome have unknown functions.
Figure1 the structures of GTP binding protein
Figure 2 Mechanisms of GTP binding protein regulaltion
Ref:
1. Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H (2000). "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes". DNA Res 7 (2): 111–20.
2. Wu G (2010). "Assays with GPCRs". Assay Development: Fundamentals and Practices.New York: Wiley.
| Cas No. | SDF | ||
| Synonyms | H2N-Lys-Val-Ile-Thr-Phe-Ile-Asp-Leu-OH | ||
| Canonical SMILES | NC(CCCCN)C(NC(C(C)C)C(NC(C(C)CC)C(NC(C(C)O)C(NC(CC1=CC=CC=C1)C(NC(C(C)CC)C(NC(CC(O)=O)C(NC(CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O | ||
| Formula | C46H77N9O12 | M.Wt | 948.16 |
| Solubility | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.0547 mL | 5.2734 mL | 10.5467 mL |
| 5 mM | 0.2109 mL | 1.0547 mL | 2.1093 mL |
| 10 mM | 0.1055 mL | 0.5273 mL | 1.0547 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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