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IAJD93 (Synonyms: Ionizable Amphiphilic Janus Dendrimer 93)

Catalog No.GC91446 Copy One-Click Copy Product Info

IAJD93 is an ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA (pKa = 6.25).

Products are for research use only. Not for human use. We do not sell to patients.

IAJD93 Chemical Structure

Size Price Stock Qty
5mg
$291.00
In stock
10mg
$553.00
In stock
25mg
$1,020.00
In stock

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Customer Reviews

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Sample solution is provided at 25 µL, 10mM.



Description of IAJD93

IAJD93 is an ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA (pKa = 6.25).1 It co-assembles with mRNA to form dendrimersome nanoparticles (DNPs) in acetate buffer. IAJD93 co-assembled with luciferase mRNA delivers the mRNA to the spleen, liver, lungs, and lymph nodes in mice.

Chemical Properties of IAJD93

Cas No. SDF
Synonyms Ionizable Amphiphilic Janus Dendrimer 93
Formula C39H78N2O6 M.Wt 671
Solubility Chloroform: Soluble,Ethanol: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of IAJD93

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.4903 mL 7.4516 mL 14.9031 mL
5 mM 298.1 μL 1.4903 mL 2.9806 mL
10 mM 149 μL 745.2 μL 1.4903 mL
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

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In vivo Formulation Calculator (Clear solution) of IAJD93

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Reviews

Review for IAJD93

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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